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It was the best of times it was the worst of times. It was the age of wisdom, it was the age of foolishness. It was the spring of hope, it was the winter of despair.

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popup.innerText =
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This sentence has inline code, useful for making references to variables, packages, versions, etc. within a sentence.

Lorem ipsum dolor sit amet.

Consectetur adipiscing elit.

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$ a * b = c ^ b $

$ 2^{\frac{n-1}{3}} $

$ \int_a^b f(x)\,dx. $

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Lorem Ipsum Dolor

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Lorem ipsum dolor sit amet, consectetur adipiscing elit, sed do eiusmod tempor incididunt ut labore et dolore magna aliqua.

Title

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List

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2026

2025

2024

2023

2022

2021

2020

2019

2018

2017

2016

2015

2014

2013

2012

2011

2009

2008

2007

List projects

RegVelo Gene-regulatory-informed dynamics of single cells

RegVelo 是一个 end-to-end 框架，将 splicing dynamics 与 gene regulatory priors 结合，用于推断单细胞 regulatory dynamics、latent time 和 perturbation effects。

software method single-cell grn

Neural crest regulatory circuits Single-cell multi-omics, spatial transcriptomics and systematic perturbation

该项目整合 multiome、Smart-seq3、MERSCOPE、Perturb-seq 与调控网络分析，用于解析 cranial neural crest migration 和 fate plasticity 的调控逻辑。

publication resource development multiomics

TEMPT Whole-genome EV-DNA methylation profiling

TEMPT 是面向 EV-DNA 的低输入、非亚硫酸氢盐全基因组甲基化测序方法，用于胃癌液体活检和细胞间通信特征识别。

method epigenomics liquid-biopsy publication

FINE-EM-seq Rapid isothermal methylome profiling for early embryos

FINE-EM-seq 是面向斑马鱼早期胚胎的快速等温扩增甲基组方法，配套提供 reproducibility analysis repo。

method epigenomics zebrafish publication

CIDER Interpretable meta-clustering for scRNA-seq integration and evaluation

CIDER 是一个用于单细胞整合数据 meta-clustering 与 integration evaluation 的可解释框架，已提供文档站点与可安装 R 包。

software single-cell integration resource

List team members

Jing Wang Master Student 武汉大学医学研究院 / 免疫与代谢前沿科学中心

Mengjun Wang Master Student 武汉大学医学研究院 / 免疫与代谢前沿科学中心

Qifeng Zhang PhD Student 武汉大学医学研究院 / 免疫与代谢前沿科学中心

Tingsu Zhang Master Student 武汉大学医学研究院 / 免疫与代谢前沿科学中心

Yanbo Xu Master Student 武汉大学医学研究院 / 免疫与代谢前沿科学中心

Yunhao Lu Undergraduate Student 武汉大学化学学院

Yuqing Li Master Student 武汉大学医学研究院 / 免疫与代谢前沿科学中心

Zhenna Jiao PhD Student 武汉大学医学研究院 / 免疫与代谢前沿科学中心

Zhiyuan Hu Principal Investigator 武汉大学医学研究院 / 免疫与代谢前沿科学中心

List blog posts

2023

Example post 3

john-doe February 23, 2023 April 29, 2026

biology medicine

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2021

2019

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[no publisher info]  ·  [no date info]  ·  [no id info]

Card

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Lorem ipsum dolor sit amet, consectetur adipiscing elit, sed do eiusmod tempor incididunt ut labore et dolore magna aliqua. Ut enim ad minim veniam, quis nostrud exercitation ullamco laboris nisi ut aliquip ex ea commodo consequat. Duis aute irure dolor in reprehenderit in voluptate velit esse cillum dolore eu fugiat nulla pariatur. Excepteur sint occaecat cupidatat non proident, sunt in culpa qui officia deserunt mollit anim id est laborum.

Code

const test = "Lorem ipsum dolor sit amet, consectetur adipiscing elit.";

Lorem ipsum dolor sit amet, consectetur adipiscing elit, sed do eiusmod tempor incididunt ut labore et dolore magna aliqua. Nulla facilisi etiam dignissim diam quis. Id aliquet lectus proin nibh nisl condimentum id venenatis a. Tristique magna sit amet purus gravida quis blandit turpis cursus. Ultrices eros in cursus turpis massa tincidunt dui ut ornare. A cras semper auctor neque vitae tempus quam pellentesque nec. At tellus at urna condimentum mattis pellentesque. Ipsum consequat nisl vel pretium. Ultrices mi tempus imperdiet nulla malesuada pellentesque elit eget gravida. Integer vitae justo eget magna fermentum iaculis eu non diam. Mus mauris vitae ultricies leo integer malesuada nunc vel. Leo integer malesuada nunc vel risus. Ornare arcu odio ut sem nulla pharetra. Purus semper eget duis at tellus at urna condimentum. Enim neque volutpat ac tincidunt vitae semper quis lectus.

Grid

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Grid of citations

2026

FINE-EM-seq: a rapid isothermal amplification method enabling comprehensive methylome profiling of zebrafish early embryos

Chenyang Ding, Qifeng Zhang, Jing Wang, Yanbo Xu, Tiantian Huang, Yanfang Du, Junjie Zhang, Xiang Zhou, Yibin Liu, Zhiyuan Hu

Cell Insight  ·  01 Jun 2026  ·  doi:10.1016/j.cellin.2026.100324

FINE-EM-seq; Cell Insight (2026).

Code

epigenomics methylation zebrafish embryo method

2025

Whole-genome methylation profiling of extracellular vesicle DNA in gastric cancer identifies intercellular communication features

Bingqian Lin, Zhenna Jiao, Shouquan Dong, Weikai Yan, Jinting Jiang, …, Xiaocheng Weng, Hongling Wang, Zhiyuan Hu, Yibin Liu, Xiang Zhou

Nature Communications  ·  29 Aug 2025  ·  doi:10.1038/s41467-025-63435-w

TEMPT; Nature Communications (2025).

Code

epigenomics methylation ev-dna liquid-biopsy method

2024

RegVelo: gene-regulatory-informed dynamics of single cells

Weixu Wang, Zhiyuan Hu, Philipp Weiler, Sarah Mayes, Marius Lange, Jingye Wang, Zhengyuan Xue, Tatjana Sauka-Spengler, Fabian J. Theis

bioRxiv  ·  11 Dec 2024  ·  doi:10.1101/2024.12.11.627935

RegVelo

Code

Docs

software single-cell rna-velocity grn method

Endothelial regulatory circuits control cranial neural crest migration and plasticity

Zhiyuan Hu, Sarah Mayes, Weixu Wang, José M. Santos-Pereira, Fabian Theis, Tatjana Sauka-Spengler

bioRxiv  ·  17 Sep 2024  ·  doi:10.1101/2024.09.17.613303

Cranial neural crest regulatory circuits.

Code

development neural-crest multiome perturb-seq grn

2023

Single-cell transcriptomics identifies a WNT7A-FZD5 signaling axis that maintains fallopian tube stem cells in patient-derived organoids

Abdulkhaliq Alsaadi, Mara Artibani, Zhiyuan Hu, Nina Wietek, Matteo Morotti, …, Jarret Adams, Francesca Silvestri, Sachdev S. Sidhu, Joan S. Brugge, Ahmed Ashour Ahmed

Cell Reports  ·  01 Nov 2023  ·  doi:10.1016/j.celrep.2023.113354

WNT7A-FZD5 organoid work; Cell Reports (2023).

organoid fallopian-tube stem-cell single-cell cancer

Near-infrared fluorescent Aza-BODIPY dyes: Rational structural design and biomedical imaging

Binyu Zhao, Linhong Liao, Yuyan Zhu, Zhiyuan Hu, Fengshou Wu

Journal of Luminescence  ·  01 Nov 2023  ·  doi:10.1016/j.jlumin.2023.120099

Highly luminescent nitrogen and sulfur co-doped carbon dots for Sn2+ and S2− sensing and dual-mode anti-counterfeiting

Linhong Liao, Xiao Lin, Kai Wang, Zhiyuan Hu, Fengshou Wu

Microchimica Acta  ·  29 Jul 2023  ·  doi:10.1007/s00604-023-05922-9

HER2 Expression in Circulating Tumor Cells as Prognostic and Predictive Biomarkers for Anti‐HER2 Therapy in Previously Treated Metastatic Colorectal Cancer

Mengting Wang, Ting Xu, Lin Shen, Jian Li, Ling Zhu, Chen Wang, Zhiyuan Hu, Ping Li, Yanlian Yang, Xicheng Wang

Advanced Therapeutics  ·  06 Jul 2023  ·  doi:10.1002/adtp.202300044

Glioblastoma cell-derived exosomes functionalized with peptides as efficient nanocarriers for synergistic chemotherapy of glioblastoma with improved biosafety

Ying Zhou, Long Wang, Lufei Chen, Wei Wu, Zhimin Yang, …, Sujun Jiang, Xuzhen Qin, Zucheng Ye, Zhiyuan Hu, Zihua Wang

Nano Research  ·  05 Jul 2023  ·  doi:10.1007/s12274-023-5921-6

Facile synthesis of efficient red-emissive carbon quantum dots as a multifunctional platform for biosensing and bioimaging

Yuyan Zhu, Guojing Li, Wei Li, Xiaogang Luo, Zhiyuan Hu, Fengshou Wu

Dyes and Pigments  ·  01 Jul 2023  ·  doi:10.1016/j.dyepig.2023.111303

GNPNAT1 is a potential biomarker correlated with immune infiltration and immunotherapy outcome in breast cancer

Renjie Yuan, Yulu Zhang, Yange Wang, Hongling Chen, Ruiming Zhang, Zhiyuan Hu, Chengsen Chai, Tingmei Chen

Frontiers in Immunology  ·  05 May 2023  ·  doi:10.3389/fimmu.2023.1152678

2022

Impact of changing treatment strategy based on circulating tumor cells on postoperative survival of breast cancer

Zihan Wang, Wei Xu, Yanlian Yang, Guoxuan Gao, Changsheng Teng, …, Yaqian Xu, Ping Li, Zhiyuan Hu, Zhongtao Zhang, Xiang Qu

Frontiers in Oncology  ·  03 Oct 2022  ·  doi:10.3389/fonc.2022.1006909

CaSee: A lightning transfer-learning model directly used to discriminate cancer/normal cells from scRNA-seq

Yuan Sh, Xiuli Zhang, Zhimin Yang, Jierong Dong, Yuanzhuo Wang, Ying Zhou, Xuejie Li, Caixia Guo, Zhiyuan Hu

Oncogene  ·  03 Oct 2022  ·  doi:10.1038/s41388-022-02478-5

HER2 status of CTCs by peptide-functionalized nanoparticles as the diagnostic biomarker of breast cancer and predicting the efficacy of anti-HER2 treatment

Mengting Wang, Yaxin Liu, Bin Shao, Xiaoran Liu, Zhiyuan Hu, Chen Wang, Huiping Li, Ling Zhu, Ping Li, Yanlian Yang

Frontiers in Bioengineering and Biotechnology  ·  28 Sep 2022  ·  doi:10.3389/fbioe.2022.1015295

Single Cell Transcriptomics identifies a WNT7A-FZD5 Signaling Axis that maintains Fallopian Tube Stem Cells in Patient-derived Organoids

Abdulkhaliq Alsaadi, Mara Artibani, Zhiyuan Hu, Nina Wietek, Matteo Morotti, …, Jarret Adams, Francesca Silvestri, Sachdev S Sidhu, Joan S. Brugge, Ahmed Ashour Ahmed

bioRxiv  ·  03 Aug 2022  ·  doi:10.1101/2022.08.02.502319

Cellular plasticity in the neural crest and cancer

Zhiyuan Hu, Tatjana Sauka-Spengler

Current Opinion in Genetics & Development  ·  01 Aug 2022  ·  doi:10.1016/j.gde.2022.101928

A novel peptide-based probe 99mTc-PEG6-RD-PDP2 for the molecular imaging of tumor PD-L2 expression

Qi Luo, Yunwei Zhang, Zihua Wang, Yining Sun, Linqing Shi, Yue Yu, Jiyun Shi, Zhiyuan Hu, Fan Wang

Chinese Chemical Letters  ·  01 Jul 2022  ·  doi:10.1016/j.cclet.2022.02.068

Correction to: An evolving story of the metastatic voyage of ovarian cancer cells: cellular and molecular orchestration of the adipose-rich metastatic microenvironment

Takeshi Motohara, Kenta Masuda, Matteo Morotti, Yiyan Zheng, Salma El-Sahhar, …, Mara Artibani, Laura Santana Gonzalez, Hidetaka Katabuchi, Hideyuki Saya, Ahmed Ashour Ahmed

Oncogene  ·  06 Jun 2022  ·  doi:10.1038/s41388-022-02356-0

An exploratory study on the detection rate of circulating tumor cells and the prediction of efficacy of neoadjuvant therapyand prognosis in patients with HER-2-positive early breast cancer

Jinmei Zhou, Jiangling Wu, Xiaopeng Hao, Ping Li, Huiqiang Zhang, …, Shaohua Zhang, Zefei Jiang, Yanlian Yang, Zhiyuan Hu, Tao Wang

Research Square Platform LLC  ·  27 May 2022  ·  doi:10.21203/rs.3.rs-1667443/v1

Prognostic Relevance of Estrogen Receptor Status in Circulating Tumor Cells in Breast Cancer Patients Treated With Endocrine Therapy

Ying Zhou, Jinmei Zhou, Jinyi Xiao, Yuehua Wang, Hao Wang, …, Ping Li, Zhiyuan Hu, Yanlian Yang, Zefei Jiang, Tao Wang

Frontiers in Oncology  ·  28 Apr 2022  ·  doi:10.3389/fonc.2022.866293

Corrigendum: Recent Advances in the Application Peptide and Peptoid in Diagnosis Biomarkers of Alzheimer's Disease in Blood

Yuxin Guo, Zhiyuan Hu, Zihua Wang

Frontiers in Molecular Neuroscience  ·  21 Feb 2022  ·  doi:10.3389/fnmol.2022.865110

Co-delivery of phagocytosis checkpoint and STING agonist by a Trojan horse nanocapsule for orthotopic glioma immunotherapy

Ying Zhou, Yuxin Guo, Lufei Chen, Xiaoli Zhang, Wei Wu, Zhimin Yang, Xuejie Li, Yuanzhuo Wang, Zhiyuan Hu, Zihua Wang

Theranostics  ·  01 Jan 2022  ·  doi:10.7150/thno.73104

2021

Recent Advances in the Application Peptide and Peptoid in Diagnosis Biomarkers of Alzheimer’s Disease in Blood

Yuxin Guo, Zhiyuan Hu, Zihua Wang

Frontiers in Molecular Neuroscience  ·  23 Dec 2021  ·  doi:10.3389/fnmol.2021.778955

Fibroblast Activation Protein‐α Responsive Peptide Assembling Prodrug Nanoparticles for Remodeling the Immunosuppressive Microenvironment and Boosting Cancer Immunotherapy

Mengqi Sun, Shaobo Yao, Linyang Fan, Zhiguo Fang, Weibing Miao, Zhiyuan Hu, Zihua Wang

Small  ·  16 Dec 2021  ·  doi:10.1002/smll.202106296

Mouse Organ-Specific Proteins and Functions

Bingyun Sun, Cynthia Lorang, Shizhen Qin, Yijuan Zhang, Ken Liu, …, Angelita G. Utleg, Zhiyuan Hu, Kai Wang, Robert L. Moritz, Leroy Hood

Cells  ·  08 Dec 2021  ·  doi:10.3390/cells10123449

Proteomics profiling of colorectal cancer progression identifies PLOD2 as a potential therapeutic target

Yingkuan Shao, Kailun Xu, Xi Zheng, Biting Zhou, Xiuli Zhang, …, Jinfan Li, Lirong Chen, Jimin Shao, Shu Zheng, Tiannan Guo

Cancer Communications  ·  04 Dec 2021  ·  doi:10.1002/cac2.12240

Application of Artificial Intelligence Modeling Technology Based on Fluid Biopsy to Diagnose Alzheimer’s Disease

Yuan Sh, Benliang Liu, Jianhu Zhang, Ying Zhou, Zhiyuan Hu, Xiuli Zhang

Frontiers in Aging Neuroscience  ·  03 Dec 2021  ·  doi:10.3389/fnagi.2021.768229

CIDER: an interpretable meta-clustering framework for single-cell RNA-seq data integration and evaluation

Zhiyuan Hu, Ahmed A. Ahmed, Christopher Yau

Genome Biology  ·  01 Dec 2021  ·  doi:10.1186/s13059-021-02561-2

CIDER; Genome Biology (2021).

Code

Docs

software single-cell integration clustering method

A mini-review on peptide-based self-assemblies and their biological applications

Chenlei Wang, Linping Fu, Zhiyuan Hu, Yeteng Zhong

Nanotechnology  ·  16 Nov 2021  ·  doi:10.1088/1361-6528/ac2fe3

Mouse Organ Specific Proteins and Functions

B. Sun, C. Lorang, S. Qin, Y. Zhang, K. Liu, …, P. Flores, Z. Hu, K. Wang, R. Moritz, L. Hood

bioRxiv  ·  01 Nov 2021  ·  doi:10.1101/2021.11.01.466788

Diagnostic AI Modeling and Pseudo Time Series Profiling of AD and PD Based on Individualized Serum Proteome Data

Jianhu Zhang, Xiuli Zhang, Yuan Sh, Benliang Liu, Zhiyuan Hu

Frontiers in Bioinformatics  ·  22 Oct 2021  ·  doi:10.3389/fbinf.2021.764497

Exome-Wide Association Study Identifies East Asian-Specific Missense Variant MTHFR C136T Influencing Homocysteine Levels in Chinese Populations RH: ExWAS of tHCY in a Chinese Population

Tianzi Liu, Mohetaboer Momin, Huiyue Zhou, Qiwen Zheng, Fangfang Fan, …, Xiao Han, Zhiyuan Hu, Changqing Zeng, Fan Liu, Yan Zhang

Frontiers in Genetics  ·  11 Oct 2021  ·  doi:10.3389/fgene.2021.717621

Cobalt-Doped Carbon Quantum Dots with Peroxidase-Mimetic Activity for Ascorbic Acid Detection through Both Fluorometric and Colorimetric Methods

Cheng Li, Jinjin Zeng, Ding Guo, Lei Liu, Liwei Xiong, Xiaogang Luo, Zhiyuan Hu, Fengshou Wu

ACS Applied Materials & Interfaces  ·  05 Oct 2021  ·  doi:10.1021/acsami.1c13198

A comprehensive assessment of the biocompatibility of Magnetospirillum gryphiswaldense MSR-1 bacterial magnetosomes in vitro and in vivo

Xiaohui Nan, Yan Teng, Jiesheng Tian, Zhiyuan Hu, Qiaojun Fang

Toxicology  ·  01 Oct 2021  ·  doi:10.1016/j.tox.2021.152949

Assessment of PD-L1 Expression on Circulating Tumor Cells for Predicting Clinical Outcomes in Patients with Cancer Receiving PD-1/PD-L1 Blockade Therapies

Zhaoli Tan, Chunyan Yue, Shoujian Ji, Chuanhua Zhao, Ru Jia, …, Qian Yu, Ping Li, Zhiyuan Hu, Yanlian Yang, Jianming Xu

The Oncologist  ·  28 Sep 2021  ·  doi:10.1002/onco.13981

Diagnostic AI Modeling and Pseudo Time Series Profiling of AD and PD Based on Individualized Serum Proteome Data

Jianhu Zhang, Xiuli zhang, Yuan Sh, Benliang Liu, Zhiyuan Hu

Research Square Platform LLC  ·  27 Jul 2021  ·  doi:10.21203/rs.3.rs-721593/v1

Application of AI Modeling Technology Based on Fluid Biopsy to Diagnose AD

Yuan Sh, Benliang Liu, Jianhu Zhang, Ying Zhou, Zhiyuan Hu, Xiuli zhang

Research Square Platform LLC  ·  27 Jul 2021  ·  doi:10.21203/rs.3.rs-731371/v1

A Microfluidic Chip for Screening and Sequencing of Monoclonal Antibody at a Single-Cell Level

Weikai Zhang, Qin Li, Fei Jia, Zhiyuan Hu, Zewen Wei

Analytical Chemistry  ·  15 Jul 2021  ·  doi:10.1021/acs.analchem.1c00918

Eating disorders treatment experiences and social support: Perspectives from service seekers in mainland China

Ruofan Ma, Manning Zhang, Jonathan M. Oakman, Jiping Wang, Siqi Zhu, Chendi Zhao, Zhiyuan Hu, NiCole T. Buchanan

International Journal of Eating Disorders  ·  08 Jun 2021  ·  doi:10.1002/EAT.23565

Biocompatibility of Bacterial Magnetosomes as MRI Contrast Agent: A Long-Term In Vivo Follow-Up Study

Xiaohui Nan, Wenjia Lai, Dan Li, Jiesheng Tian, Zhiyuan Hu, Qiaojun Fang

Nanomaterials  ·  07 May 2021  ·  doi:10.3390/nano11051235

Adipocyte-like signature in ovarian cancer minimal residual disease identifies metabolic vulnerabilities of tumor initiating cells

Mara Artibani, Kenta Masuda, Zhiyuan Hu, Pascal C. Rauher, Garry Mallett, …, Christer S. Ejsing, Robin W. Klemm, Christopher Yau, Tatjana Sauka-Spengler, Ahmed A. Ahmed

JCI Insight  ·  04 May 2021  ·  doi:10.1172/jci.insight.147929

Application of Artificial Intelligence Modeling Technology Based on Multi-Omics in Noninvasive Diagnosis of Inflammatory Bowel Disease

Qiongrong Huang, Xiuli Zhang, Zhiyuan Hu

Journal of Inflammation Research  ·  01 May 2021  ·  doi:10.2147/JIR.S306816

The Zinc Finger Protein Zbtb18 Represses Expression of Class I Phosphatidylinositol 3-Kinase Subunits and Inhibits Plasma Cell Differentiation

Bin Xie, Tariq E Khoyratty, Enas Abu-Shah, Pablo F Cespedes, Andrew J MacLean, …, Zhiyuan Hu, Ahmed A Ahmed, Michael L Dustin, Irina A Udalova, Tal I Arnon

The Journal of Immunology  ·  01 Apr 2021  ·  doi:10.4049/jimmunol.2000367

Novel Peptide-Based Magnetic Nanoparticle for Mesenchymal Circulating Tumor Cells Detection

Fei Jia, Yuehua Wang, Zhiguo Fang, Jierong Dong, Fanghao Shi, Weikai Zhang, Zihua Wang, Zhiyuan Hu

Analytical Chemistry  ·  31 Mar 2021  ·  doi:10.1021/acs.analchem.1c00577

An interpretable meta-clustering framework for single-cell RNA-Seq data integration and evaluation

Zhiyuan Hu, Ahmed A. Ahmed, Christopher Yau

bioRxiv  ·  30 Mar 2021  ·  doi:10.1101/2021.03.29.437525

Promises and challenges of adoptive T-cell therapies for solid tumours.

Matteo Morotti, Ashwag Albukhari, Abdulkhaliq Alsaadi, Mara Artibani, James D Brenton, …, Helen White, Nina Wietek, David N Church, David C Wedge, Ahmed A Ahmed

British journal of cancer  ·  29 Mar 2021  ·  pmid:33782566

Mechanistic Drivers of Müllerian Duct Development and Differentiation Into the Oviduct

Laura Santana Gonzalez, Ioanna A. Rota, Mara Artibani, Matteo Morotti, Zhiyuan Hu, Nina Wietek, Abdulkhaliq Alsaadi, Ashwag Albukhari, Tatjana Sauka-Spengler, Ahmed A. Ahmed

Frontiers in Cell and Developmental Biology  ·  08 Mar 2021  ·  doi:10.3389/fcell.2021.605301

The Oxford Classic Links Epithelial-to-Mesenchymal Transition to Immunosuppression in Poor Prognosis Ovarian Cancers

Zhiyuan Hu, Paula Cunnea, Zhe Zhong, Haonan Lu, Oloruntoba I. Osagie, …, Joanna Hester, Ashwag Albukhari, Eric O. Aboagye, Christina Fotopoulou, Ahmed Ahmed

Clinical Cancer Research  ·  01 Mar 2021  ·  doi:10.1158/1078-0432.CCR-20-2782

Subtraction-free and bisulfite-free specific sequencing of 5-methylcytosine and its oxidized derivatives at base resolution

Yibin Liu, Zhiyuan Hu, Jingfei Cheng, Paulina Siejka-Zielińska, Jinfeng Chen, Masato Inoue, Ahmed Ashour Ahmed, Chun-Xiao Song

Nature Communications  ·  27 Jan 2021  ·  doi:10.1038/s41467-021-20920-2

A Microfluidic Chip for Efficient Circulating Tumor Cells Enrichment, Screening, and Single‐Cell RNA Sequencing

Fanghao Shi, Fei Jia, Zewen Wei, Yan Ma, Zhiguo Fang, Weikai Zhang, Zhiyuan Hu

PROTEOMICS  ·  12 Jan 2021  ·  doi:10.1002/pmic.202000060

BCAR1 plays critical roles in the formation and immunoevasion of invasive circulating tumor cells in lung adenocarcinoma

Chun-Guo Mao, Sha-sha Jiang, Xiao-yang Wang, Shao-Lin Tao, Bin Jiang, …, Tan Long, Hua Jin, Qun-You Tan, Yi Huang, Bo Deng

International Journal of Biological Sciences  ·  01 Jan 2021  ·  doi:10.7150/ijbs.61790

2020

Ultrasensitive Gastric Cancer Circulating Tumor Cellular CLDN18.2 RNA Detection Based on a Molecular Beacon

Linyang Fan, Xiaoyi Chong, Minzhi Zhao, Fei Jia, Zihua Wang, …, Yanlian Yang, Zhiyuan Hu, Qin Li, Xiaotian Zhang, Lin Shen

Analytical Chemistry  ·  14 Dec 2020  ·  doi:10.1021/acs.analchem.0c04055

A P4 medicine perspective of gut microbiota and prediabetes: Systems analysis and personalized intervention

Qiongrong Huang, Qiaojun Fang, Zhiyuan Hu

Journal of Translational Internal Medicine  ·  01 Sep 2020  ·  doi:10.2478/jtim-2020-0020

A Novel CD133- and EpCAM-Targeted Liposome With Redox-Responsive Properties Capable of Synergistically Eliminating Liver Cancer Stem Cells

Zihua Wang, Mengqi Sun, Wang Li, Linyang Fan, Ying Zhou, Zhiyuan Hu

Frontiers in Chemistry  ·  11 Aug 2020  ·  doi:10.3389/fchem.2020.00649

Efficient isolation and quantification of circulating tumor cells in non-small cell lung cancer patients using peptide-functionalized magnetic nanoparticles

Naixin Liang, Lei Liu, Ping Li, Yuan Xu, Yingshuo Hou, …, Huihui Xu, Qian Yu, Shanqing Li, Zhiyuan Hu, Yanlian Yang

Journal of Thoracic Disease  ·  01 Aug 2020  ·  doi:10.21037/jtd-20-1026A

Enhanced Immunogenicity of Mitochondrial-Localized Proteins in Cancer Cells

Gennaro Prota, Uzi Gileadi, Margarida Rei, Ana Victoria Lechuga-Vieco, Ji-Li Chen, …, Jan Rehwinkel, Jose A. Enríquez, Ahmed A. Ahmed, Ton N. Schumacher, Vincenzo Cerundolo

Cancer Immunology Research  ·  01 May 2020  ·  doi:10.1158/2326-6066.cir-19-0467

Imaging and monitoring HER2 expression in breast cancer during trastuzumab therapy with a peptide probe 99mTc-HYNIC-H10F

Yue Wu, Liqiang Li, Zihua Wang, Jiyun Shi, Zhiyuan Hu, Shi Gao, Weibing Miao, Qingjie Ma, Chengyan Dong, Fan Wang

European Journal of Nuclear Medicine and Molecular Imaging  ·  13 Mar 2020  ·  doi:10.1007/s00259-020-04754-6

Diagnosis of Mild Cognitive Impairment and Alzheimer’s Disease by the Plasma and Serum Amyloid-beta 42 Assay through Highly Sensitive Peptoid Nanosheet Sensor

Houqian Gao, Mingzhu Liu, Zijian Zhao, Caixia Yang, Ling Zhu, Yanning Cai, Yanlian Yang, Zhiyuan Hu

ACS Applied Materials & Interfaces  ·  03 Feb 2020  ·  doi:10.1021/acsami.0c00370

The Repertoire of Serous Ovarian Cancer Non-genetic Heterogeneity Revealed by Single-Cell Sequencing of Normal Fallopian Tube Epithelial Cells

Zhiyuan Hu, Mara Artibani, Abdulkhaliq Alsaadi, Nina Wietek, Matteo Morotti, …, Stephanie Jones, Vincenzo Cerundolo, Tatjana Sauka-Spengler, Christopher Yau, Ahmed Ashour Ahmed

Cancer Cell  ·  01 Feb 2020  ·  doi:10.1016/j.ccell.2020.01.003

Single-cell profiling of normal fallopian tube epithelial cells; Cancer Cell (2020).

single-cell cancer ovarian-cancer heterogeneity

Drug-internalized bacterial swimmers for magnetically manipulable tumor-targeted drug delivery

Zhichu Xiang, Gexuan Jiang, Di Fan, Jiesheng Tian, Zhiyuan Hu, Qiaojun Fang

Nanoscale  ·  01 Jan 2020  ·  doi:10.1039/d0nr01892a

A microfluidic chip for screening high-producing hybridomas at single cell level

Weikai Zhang, Ren Li, Fei Jia, Zhiyuan Hu, Qin Li, Zewen Wei

Lab on a Chip  ·  01 Jan 2020  ·  doi:10.1039/d0lc00847h

2019

Etiologic and treatment conceptualizations of disordered eating symptoms among mainland Chinese therapists

Ruofan Ma, Kevin P. Capobianco, NiCole T. Buchanan, Zhiyuan Hu, Jonathan M. Oakman

International Journal of Eating Disorders  ·  24 Nov 2019  ·  doi:10.1002/eat.23204

<p>Breakthroughs in medicine and bioimaging with up-conversion nanoparticles</p>

Iman Rostami, Hamideh Rezvani, Zhiyuan Hu, Sarah H Shahmoradian

International Journal of Nanomedicine  ·  01 Sep 2019  ·  doi:10.2147/IJN.S221433

A Novel Peptide Probe for Identification of PLS3-Expressed Cancer Cells

Fanghao Shi, Yan Ma, Yixia Qian, Yuehua Wang, Zihua Wang, Minzhi Zhao, Zhiyuan Hu

Analytical Chemistry  ·  11 Jul 2019  ·  doi:10.1021/acs.analchem.9b01061

The repertoire of serous ovarian cancer non-genetic heterogeneity revealed by single-cell sequencing of normal fallopian tube epithelial cells

Zhiyuan Hu, Mara Artibani, Abdulkhaliq Alsaadi, Nina Wietek, Matteo Morotti, …, Hooman Soleymani majd, Vincenzo Cerundolo, Tatjana Sauka-Spengler, Christopher Yau, Ahmed A. Ahmed

bioRxiv  ·  17 Jun 2019  ·  doi:10.1101/672626

Community assessment to advance computational prediction of cancer drug combinations in a pharmacogenomic screen

Michael P. Menden, Dennis Wang, Mike J. Mason, Bence Szalai, Krishna C. Bulusu, …, Stephen Fawell, Gustavo Stolovitzky, Justin Guinney, Jonathan R. Dry, Julio Saez-Rodriguez

Nature Communications  ·  17 Jun 2019  ·  doi:10.1038/s41467-019-09799-2

Peptosome Coadministration Improves Nanoparticle Delivery to Tumors through NRP1-Mediated Co-Endocytosis

Zhichu Xiang, Gexuan Jiang, Xiaoliang Yang, Di Fan, Xiaohui Nan, Dan Li, Zhiyuan Hu, Qiaojun Fang

Biomolecules  ·  05 May 2019  ·  doi:10.3390/biom9050172

Boosting the Theranostic Effect of Liposomal Probes toward Prominin-1 through Optimized Dual-Site Targeting

Yuehua Wang, Fei Jia, Zihua Wang, Yixia Qian, Linyang Fan, He Gong, Aiqin Luo, Jian Sun, Zhiyuan Hu, Weizhi Wang

Analytical Chemistry  ·  28 Mar 2019  ·  doi:10.1021/acs.analchem.9b00622

Plastin 3 down-regulation augments the sensitivity of MDA-MB-231 cells to paclitaxel via the p38 MAPK signalling pathway

Yan Ma, Wenjia Lai, Minzhi Zhao, Chunyan Yue, Fanghao Shi, Ren Li, Zhiyuan Hu

Artificial Cells, Nanomedicine, and Biotechnology  ·  04 Mar 2019  ·  doi:10.1080/21691401.2019.1576707

Microenvironment‐Induced In Situ Self‐Assembly of Polymer–Peptide Conjugates That Attack Solid Tumors Deeply

Yong Cong, Lei Ji, Yu‐Juan Gao, Fu‐Hua Liu, Dong‐Bing Cheng, Zhiyuan Hu, Zeng‐Ying Qiao, Hao Wang

Angewandte Chemie International Edition  ·  27 Feb 2019  ·  doi:10.1002/anie.201900135

Detection of Parkinson’s Disease through the Peptoid Recognizing α-Synuclein in Serum

Houqian Gao, Zijian Zhao, Zhaohui He, Huayi Wang, Mingzhu Liu, Zhiyuan Hu, Oumei Cheng, Yanlian Yang, Ling Zhu

ACS Chemical Neuroscience  ·  25 Jan 2019  ·  doi:10.1021/acschemneuro.8b00540

Anti-PD-1 Antibody SHR-1210 Combined with Apatinib for Advanced Hepatocellular Carcinoma, Gastric, or Esophagogastric Junction Cancer: An Open-label, Dose Escalation and Expansion Study

Jianming Xu, Yun Zhang, Ru Jia, Chunyan Yue, Lianpeng Chang, …, Yan Wang, Xin Yi, Zhiyuan Hu, Jianjun Zou, Quanren Wang

Clinical Cancer Research  ·  15 Jan 2019  ·  doi:10.1158/1078-0432.CCR-18-2484

Proteomic profiling of RAW264.7 macrophage cells exposed to graphene oxide: insights into acute cellular responses

Xiaoliang Yang, Yan Zhang, Wenjia Lai, Zhichu Xiang, Bin Tu, Dan Li, Xiaohui Nan, Chunying Chen, Zhiyuan Hu, Qiaojun Fang

Nanotoxicology  ·  02 Jan 2019  ·  doi:10.1080/17435390.2018.1530389

Tumor-microenvironment controlled nanomicelles with AIE property for boosting cancer therapy and apoptosis monitoring

Yixia Qian, Yuehua Wang, Fei Jia, Zihua Wang, Chunyan Yue, Weikai Zhang, Zhiyuan Hu, Weizhi Wang

Biomaterials  ·  01 Jan 2019  ·  doi:10.1016/j.biomaterials.2018.10.003

Synergetic estrogen receptor-targeting liposome nanocarriers with anti-phagocytic properties for enhanced tumor theranostics

Yuehua Wang, Zihua Wang, Yixia Qian, Linyang Fan, Chunyan Yue, Fei Jia, Jian Sun, Zhiyuan Hu, Weizhi Wang

Journal of Materials Chemistry B  ·  01 Jan 2019  ·  doi:10.1039/c8tb03351j

MMP-2-Controlled Transforming Micelles for Heterogeneic Targeting and Programmable Cancer Therapy

Zihua Wang, Yuehua Wang, Xiangqian Jia, Qiuju Han, Yixia Qian, Qian Li, Junfeng Xiang, Qian Wang, Zhiyuan Hu, Weizhi Wang

Theranostics  ·  01 Jan 2019  ·  doi:10.7150/thno.30915

Device for whole genome sequencing single circulating tumor cells from whole blood

Ren Li, Fei Jia, Weikai Zhang, Fanghao Shi, Zhiguo Fang, Hong Zhao, Zhiyuan Hu, Zewen Wei

Lab on a Chip  ·  01 Jan 2019  ·  doi:10.1039/c9lc00473d

A Microfluidic Chip for Screening High-Producing Hybridomas at the Single-Cell Level

Wei K. Zhang, Ren Li, Zhi G. Fang, Zhi Y. Hu, Ze W. Wei, Qin Li

2019 IEEE 32nd International Conference on Micro Electro Mechanical Systems (MEMS)  ·  01 Jan 2019  ·  doi:10.1109/MEMSYS.2019.8870728

A Microfluidic Chip for CTC Whole Genome Sequencing

Li Ren, Jia Fei, W.K. Zhang, Z.G. Fang, Z.Y. Hu, Z.W. Wei

2019 IEEE 32nd International Conference on Micro Electro Mechanical Systems (MEMS)  ·  01 Jan 2019  ·  doi:10.1109/MEMSYS.2019.8870769

2018

An evolving story of the metastatic voyage of ovarian cancer cells: cellular and molecular orchestration of the adipose-rich metastatic microenvironment

Takeshi Motohara, Kenta Masuda, Matteo Morotti, Yiyan Zheng, Salma El-Sahhar, …, Mara Artibani, Laura Santana Gonzalez, Hidetaka Katabuchi, Hideyuki Saya, Ahmed Ashour Ahmed

Oncogene  ·  19 Dec 2018  ·  doi:10.1038/s41388-018-0637-x

Targeting Peptide‐Based Probes for Molecular Imaging and Diagnosis

Weizhi Wang, Zhiyuan Hu

Advanced Materials  ·  07 Dec 2018  ·  doi:10.1002/adma.201804827

Prospect of liquid biopsy application for precise medication of PD-1/PD-L1 inhibitor

Yuehua Wang, Mengqi Sun, Zhiyuan Hu

Chinese Science Bulletin  ·  21 Nov 2018  ·  doi:10.1360/N972018-00859

Design of a Simple and Practical Nanosystem Coordinates Tumor Targeting and Penetration for Improved Theranostics

Zhichu Xiang, Xiaoliang Yang, Gexuan Jiang, Di Fan, Lingling Geng, Hao Wang, Zhiyuan Hu, Qiaojun Fang

Advanced Therapeutics  ·  21 Oct 2018  ·  doi:10.1002/adtp.201800107

Quantitative proteomic analysis to the first commercialized liposomal paclitaxel nano-platform Lipusu revealed the molecular mechanism of the enhanced anti-tumor effect

Minzhi Zhao, Haiyun Li, Linyang Fan, Yan Ma, He Gong, Wenjia Lai, Qiaojun Fang, Zhiyuan Hu

Artificial Cells, Nanomedicine, and Biotechnology  ·  19 Sep 2018  ·  doi:10.1080/21691401.2018.1489822

Quantitative Proteomic Analysis of Cell Responses to Electroporation, a Classical Gene Delivery Approach

Minzhi Zhao, Deyao Zhao, Yan Ma, Zhiyuan Hu, Zewen Wei

PROTEOMICS  ·  01 Aug 2018  ·  doi:10.1002/pmic.201800127

A Plasmon-Enhanced Fluorescence Protein Microchip with High-Sensitivity for Multiple Islet Autoantibodies Measurements in Autoimmune Diabetes Diagnosis

Yiwen Liu, Jine Li, Juanxia Wu, Fan Ping, Lingling Xu, Qi Sun, Ying Liu, Yuxiu Li, Zhiyuan Hu, Liming Xie

Journal of Biomedical Nanotechnology  ·  01 Aug 2018  ·  doi:10.1166/jbn.2018.2600

IGFBP7 is associated to prognosis and could suppress cell survival in cholangiocarcinoma

Chunyan Yue, Manyi Yang, Qinggang Tian, Fongming Mo, Jian Peng, Yan Ma, Yanning Huang, Dongcui Wang, Yuehua Wang, Zhiyuan Hu

Artificial Cells, Nanomedicine, and Biotechnology  ·  10 Jul 2018  ·  doi:10.1080/21691401.2018.1470524

Molecular Cancer Imaging in the Second Near‐Infrared Window Using a Renal‐Excreted NIR‐II Fluorophore‐Peptide Probe

Weizhi Wang, Zhuoran Ma, Shoujun Zhu, Hao Wan, Jingying Yue, …, Hongpeng Gao, Junshan Ruan, Zhiyuan Hu, Yongye Liang, Hongjie Dai

Advanced Materials  ·  23 Apr 2018  ·  doi:10.1002/adma.201800106

Dynamic change of PD-L1 expression on circulating tumor cells in advanced solid tumor patients undergoing PD-1 blockade therapy

Chunyan Yue, Yubo Jiang, Ping Li, Yuehua Wang, Jian Xue, …, Ruina Wang, Yongjun Dang, Zhiyuan Hu, Yanlian Yang, Jianming Xu

OncoImmunology  ·  06 Mar 2018  ·  doi:10.1080/2162402X.2018.1438111

pH-Triggered Peptide Self-Assembly for Targeting Imaging and Therapy toward Angiogenesis with Enhanced Signals

Yixia Qian, Weizhi Wang, Zihua Wang, Xiangqian Jia, Qiuju Han, Iman Rostami, Yuehua Wang, Zhiyuan Hu

ACS Applied Materials & Interfaces  ·  14 Feb 2018  ·  doi:10.1021/acsami.8b00583

Generation of a monoclonal antibody recognizing the heavily glycosylated CD45 protein and its application on identifying circulating tumor cells

Weikai Zhang, Zhitao Li, Zihua Wang, Chunyan Yue, Hui Zheng, Ren Li, Mingxing Zhou, Zhiyuan Hu, Zewen Wei, Qin Li

PLOS ONE  ·  09 Feb 2018  ·  doi:10.1371/journal.pone.0192506

Device To Study the Cell Invasion Behavior and Phenotypic Profile at Single Cell Level

Ren Li, Yan Ma, Minzhi Zhao, Zhiyuan Hu, Zewen Wei

Analytical Chemistry  ·  22 Jan 2018  ·  doi:10.1021/acs.analchem.7b03294

Multiple single cell screening and DNA MDA amplification chip for oncogenic mutation profiling

Ren Li, Mingxing Zhou, Chunyan Yue, Weikai Zhang, Yan Ma, Hailin Peng, Zhiyuan Hu, Zewen Wei

Lab on a Chip  ·  01 Jan 2018  ·  doi:10.1039/c7lc00924k

2017

Identifying EGFR-Expressed Cells and Detecting EGFR Multi-Mutations at Single-Cell Level by Microfluidic Chip

Ren Li, Mingxing Zhou, Jine Li, Zihua Wang, Weikai Zhang, Chunyan Yue, Yan Ma, Hailin Peng, Zewen Wei, Zhiyuan Hu

Nano-Micro Letters  ·  14 Nov 2017  ·  doi:10.1007/s40820-017-0168-y

Boosting the down-shifting luminescence of rare-earth nanocrystals for biological imaging beyond 1500 nm

Yeteng Zhong, Zhuoran Ma, Shoujun Zhu, Jingying Yue, Mingxi Zhang, …, Weizhi Wang, Ngan F. Huang, Jian Luo, Zhiyuan Hu, Hongjie Dai

Nature Communications  ·  29 Sep 2017  ·  doi:10.1038/s41467-017-00917-6

Reconfigurable Peptide Nanotherapeutics at Tumor Microenvironmental pH

Zeng-Ying Qiao, Wen-Jing Zhao, Yu-Juan Gao, Yong Cong, Lina Zhao, Zhiyuan Hu, Hao Wang

ACS Applied Materials & Interfaces  ·  31 Aug 2017  ·  doi:10.1021/acsami.7b09033

A pan-cancer genome-wide analysis reveals tumour dependencies by induction of nonsense-mediated decay

Zhiyuan Hu, Christopher Yau, Ahmed Ashour Ahmed

Nature Communications  ·  26 Jun 2017  ·  doi:10.1038/ncomms15943

Antibody‐Mimetic Peptoid Nanosheet for Label‐Free Serum‐Based Diagnosis of Alzheimer's Disease

Ling Zhu, Zijian Zhao, Peng Cheng, Zhaohui He, Zhiqiang Cheng, Jiaxi Peng, Huayi Wang, Chen Wang, Yanlian Yang, Zhiyuan Hu

Advanced Materials  ·  12 Jun 2017  ·  doi:10.1002/adma.201700057

Peptide probes derived from pertuzumab by molecular dynamics modeling for HER2 positive tumor imaging

Xiaoliang Yang, Zihua Wang, Zhichu Xiang, Dan Li, Zhiyuan Hu, Wei Cui, Lingling Geng, Qiaojun Fang

PLOS Computational Biology  ·  13 Apr 2017  ·  doi:10.1371/journal.pcbi.1005441

Interaction of gold and silver nanoparticles with human plasma: Analysis of protein corona reveals specific binding patterns

Wenjia Lai, Qingsong Wang, Lumeng Li, Zhiyuan Hu, Jiankui Chen, Qiaojun Fang

Colloids and Surfaces B: Biointerfaces  ·  01 Apr 2017  ·  doi:10.1016/j.colsurfb.2017.01.037

Nanoparticle abraxane possesses impaired proliferation in A549 cells due to the underexpression of glucosamine 6-phosphate N-acetyltransferase 1 (GNPNAT1/GNA1)

Minzhi Zhao, Haiyun Li, Yan Ma, He Gong, Shu Yang, Qiaojun Fang, Zhiyuan Hu

International Journal of Nanomedicine  ·  01 Mar 2017  ·  doi:10.2147/IJN.S129976

SPECT/CT Imaging of the Novel HER2-Targeted Peptide Probe ^99mTc-HYNIC-H6F in Breast Cancer Mouse Models

Liqiang Li, Yue Wu, Zihua Wang, Bing Jia, Zhiyuan Hu, Chengyan Dong, Fan Wang

Journal of Nuclear Medicine  ·  19 Jan 2017  ·  doi:10.2967/jnumed.116.183863

Tumor detection using magnetosome nanoparticles functionalized with a newly screened EGFR/HER2 targeting peptide

Zhichu Xiang, Xiaoliang Yang, Junjie Xu, Wenjia Lai, Zihua Wang, Zhiyuan Hu, Jiesheng Tian, Lingling Geng, Qiaojun Fang

Biomaterials  ·  01 Jan 2017  ·  doi:10.1016/j.biomaterials.2016.11.022

Targeting peptide functionalized liposomes towards aminopeptidase N for precise tumor diagnosis and therapy

Xiangqian Jia, Qiuju Han, Zihua Wang, Yixia Qian, Yunhong Jia, Weizhi Wang, Zhiyuan Hu

Biomaterials Science  ·  01 Jan 2017  ·  doi:10.1039/c6bm00898d

Precisely Enumerating Circulating Tumor Cells Utilizing a Multi-Functional Microfluidic Chip and Unique Image Interpretation Algorithm

Mingxing Zhou, Hui Zheng, Zhaoba Wang, Ren Li, Xiaoran Liu, Weikai Zhang, Zihua Wang, Huiping Li, Zewen Wei, Zhiyuan Hu

Theranostics  ·  01 Jan 2017  ·  doi:10.7150/thno.20440

2016

Antiamyloidogenic Activity of Aβ42-Binding Peptoid in Modulating Amyloid Oligomerization

Zijian Zhao, Ling Zhu, Haiyun Li, Peng Cheng, Jiaxi Peng, Yudan Yin, Yang Yang, Chen Wang, Zhiyuan Hu, Yanlian Yang

Small  ·  07 Oct 2016  ·  doi:10.1002/smll.201602857

Switchable Liposomes: Targeting-Peptide-Functionalized and pH-Triggered Cytoplasmic Delivery

Qiuju Han, Weizhi Wang, Xiangqian Jia, Yixia Qian, Qian Li, Zihua Wang, Weikai Zhang, Shu Yang, Yunhong Jia, Zhiyuan Hu

ACS Applied Materials & Interfaces  ·  12 Jul 2016  ·  doi:10.1021/acsami.6b05678

Self-Assembled ROS-Sensitive Polymer–Peptide Therapeutics Incorporating Built-in Reporters for Evaluation of Treatment Efficacy

Zeng-Ying Qiao, Wen-Jing Zhao, Yong Cong, Di Zhang, Zhiyuan Hu, Zhong-Yu Duan, Hao Wang

Biomacromolecules  ·  08 Apr 2016  ·  doi:10.1021/acs.biomac.6b00041

Response of Human Osteoblast to n-HA/PEEK—Quantitative Proteomic Study of Bio-effects of Nano-Hydroxyapatite Composite

Minzhi Zhao, Haiyun Li, Xiaochen Liu, Jie Wei, Jianguo Ji, Shu Yang, Zhiyuan Hu, Shicheng Wei

Scientific Reports  ·  09 Mar 2016  ·  doi:10.1038/srep22832

Micromixer Based Preparation of Functionalized Liposomes and Targeting Drug Delivery

Xiangqian Jia, Weizhi Wang, Qiuju Han, Zihua Wang, Yunhong Jia, Zhiyuan Hu

ACS Medicinal Chemistry Letters  ·  16 Feb 2016  ·  doi:10.1021/acsmedchemlett.6b00028

Switchable probes: pH-triggered and VEGFR2 targeted peptides screening through imprinting microarray

Yixia Qian, Weizhi Wang, Zihua Wang, Qiuju Han, Xiangqian Jia, Shu Yang, Zhiyuan Hu

Chemical Communications  ·  01 Jan 2016  ·  doi:10.1039/c6cc01302c

Peptide-conjugated PEGylated PAMAM as a highly affinitive nanocarrier towards HER2-overexpressing cancer cells

Iman Rostami, ZiJian Zhao, ZiHua Wang, WeiKai Zhang, Yeteng Zhong, Qiang Zeng, XinRu Jia, ZhiYuan Hu

RSC Advances  ·  01 Jan 2016  ·  doi:10.1039/C6RA19552K

Peptide functionalized targeting liposomes: for nanoscale drug delivery towards angiogenesis

Qiuju Han, Xiangqian Jia, Yixia Qian, Zihua Wang, Shu Yang, Yunhong Jia, Weizhi Wang, Zhiyuan Hu

Journal of Materials Chemistry B  ·  01 Jan 2016  ·  doi:10.1039/c6tb01823h

High-Throughput Peptide Screening on a Bimodal Imprinting Chip Through MS-SPRi Integration

Weizhi Wang, Qiaojun Fang, Zhiyuan Hu

Methods in Molecular Biology  ·  01 Jan 2016  ·  doi:10.1007/978-1-4939-3037-1_9

HER2 Targeting Peptides Screening and Applications in Tumor Imaging and Drug Delivery

Lingling Geng, Zihua Wang, Xiangqian Jia, Qiuju Han, Zhichu Xiang, …, Di Zhang, Xiangli Bu, Weizhi Wang, Zhiyuan Hu, Qiaojun Fang

Theranostics  ·  01 Jan 2016  ·  doi:10.7150/thno.14302

2015

Pathological‐Condition‐Driven Construction of Supramolecular Nanoassemblies for Bacterial Infection Detection

Li‐Li Li, Huai‐Lei Ma, Guo‐Bin Qi, Di Zhang, Faquan Yu, Zhiyuan Hu, Hao Wang

Advanced Materials  ·  16 Nov 2015  ·  doi:10.1002/adma.201503437

Discovering of Tumor‐targeting Peptides using Bi‐functional Microarray

Weizhi Wang, Zihua Wang, Xiangli Bu, Ren Li, Mingxing Zhou, Zhiyuan Hu

Advanced Healthcare Materials  ·  09 Nov 2015  ·  doi:10.1002/adhm.201500724

Energy Migration Engineering of Bright Rare‐Earth Upconversion Nanoparticles for Excitation by Light‐Emitting Diodes

Yeteng Zhong, Iman Rostami, Zihua Wang, Hongjie Dai, Zhiyuan Hu

Advanced Materials  ·  22 Sep 2015  ·  doi:10.1002/adma.201502272

Quantitative Proteomic Analysis of Cellular Resistance to the Nanoparticle Abraxane

Minzhi Zhao, Haiyun Li, Xiangli Bu, Chunni Lei, Qiaojun Fang, Zhiyuan Hu

ACS Nano  ·  09 Sep 2015  ·  doi:10.1021/acsnano.5b03677

Microarray Based Screening of Peptide Nano Probes for HER2 Positive Tumor

Zihua Wang, Weizhi Wang, Xiangli Bu, Zewen Wei, Lingling Geng, …, Shu Yang, Fan Wang, Christopher Lausted, Leroy Hood, Zhiyuan Hu

Analytical Chemistry  ·  06 Aug 2015  ·  doi:10.1021/acs.analchem.5b01588

Abraxane, the Nanoparticle Formulation of Paclitaxel Can Induce Drug Resistance by Up-Regulation of P-gp

Minzhi Zhao, Chunni Lei, Yadong Yang, Xiangli Bu, Huailei Ma, He Gong, Juan Liu, Xiangdong Fang, Zhiyuan Hu, Qiaojun Fang

PLOS ONE  ·  16 Jul 2015  ·  doi:10.1371/journal.pone.0131429

Label-free detection microarray for novel peptide ligands screening base on MS–SPRi combination

Weizhi Wang, Di Zhang, Zewen Wei, Zihua Wang, Xiangli Bu, Shu Yang, Qiaojun Fang, Zhiyuan Hu

Talanta  ·  01 Mar 2015  ·  doi:10.1016/j.talanta.2014.12.012

A Pliable Electroporation Patch (ep-Patch) for Efficient Delivery of Nucleic Acid Molecules into Animal Tissues with Irregular Surface Shapes

Zewen Wei, Yuanyu Huang, Deyao Zhao, Zhiyuan Hu, Zhihong Li, Zicai Liang

Scientific Reports  ·  05 Jan 2015  ·  doi:10.1038/srep07618

Structure-based Design of Peptides with High Affinity and Specificity to HER2 Positive Tumors

Lingling Geng, Zihua Wang, Xiaoliang Yang, Dan Li, Wenxi Lian, …, Weizhi Wang, Xiangli Bu, Wenjia Lai, Zhiyuan Hu, Qiaojun Fang

Theranostics  ·  01 Jan 2015  ·  doi:10.7150/thno.12398

Label-free detection of Alzheimer’s disease through the ADP3 peptoid recognizing the serum amyloid-beta42 peptide

Zijian Zhao, Ling Zhu, Xiangli Bu, Huailei Ma, Shu Yang, Yanlian Yang, Zhiyuan Hu

Chemical Communications  ·  01 Jan 2015  ·  doi:10.1039/c4cc07037b

Fast assembling microarrays of superparamagnetic Fe₃O₄@Au nanoparticle clusters as reproducible substrates for surface-enhanced Raman scattering

Min Ye, Zewen Wei, Fei Hu, Jianxin Wang, Guanglu Ge, Zhiyuan Hu, Mingwang Shao, Shuit-Tong Lee, Jian Liu

Nanoscale  ·  01 Jan 2015  ·  doi:10.1039/c5nr02491a

Distinguishing of tumor cell-targeting peptide ligands through a color-encoding microarray

Zihua Wang, Weizhi Wang, Lingling Geng, Zhiyuan Hu

Lab on a Chip  ·  01 Jan 2015  ·  doi:10.1039/c5lc01010a

Correction: A continuous flow microfluidic-MS system for efficient OBOC screening

Weizhi Wang, Zewen Wei, Zihua Wang, Huailei Ma, Xiangli Bu, Zhiyuan Hu

RSC Advances  ·  01 Jan 2015  ·  doi:10.1039/c4ra90057j

2014

Rapid Screening of Peptide Probes through In Situ Single-Bead Sequencing Microarray

Weizhi Wang, Zewen Wei, Di Zhang, Huailei Ma, Zihua Wang, …, Christopher Lausted, Leroy Hood, Qiaojun Fang, Hao Wang, Zhiyuan Hu

Analytical Chemistry  ·  14 Nov 2014  ·  doi:10.1021/ac503454z

Flow-Through Cell Electroporation Microchip Integrating Dielectrophoretic Viable Cell Sorting

Zewen Wei, Xueming Li, Deyao Zhao, Hao Yan, Zhiyuan Hu, Zicai Liang, Zhihong Li

Analytical Chemistry  ·  06 Oct 2014  ·  doi:10.1021/ac502294e

Betaine homocysteine methyltransferase (BHMT) as a specific and sensitive blood marker for acute liver injury

Huailei Ma, Jing Ning, Xin Jin, Chunming Mao, Xiangli Bu, …, Kun Wang, Christopher Lausted, Leroy Hood, Jiankui Chen, Zhiyuan Hu

Biomarkers  ·  21 Aug 2014  ·  doi:10.3109/1354750X.2014.951880

Label-Free Quantitative Detection of Tumor-Derived Exosomes through Surface Plasmon Resonance Imaging

Ling Zhu, Kun Wang, Jian Cui, Huan Liu, Xiangli Bu, …, He Gong, Christopher Lausted, Leroy Hood, Guang Yang, Zhiyuan Hu

Analytical Chemistry  ·  11 Aug 2014  ·  doi:10.1021/ac5023056

Bimodal Imprint Chips for Peptide Screening: Integration of High-Throughput Sequencing by MS and Affinity Analyses by Surface Plasmon Resonance Imaging

Weizhi Wang, Menglin Li, Zewen Wei, Zihua Wang, Xiangli Bu, …, Yuqiao Wang, Ying Liu, Qin Li, Qiaojun Fang, Zhiyuan Hu

Analytical Chemistry  ·  24 Mar 2014  ·  doi:10.1021/ac500465e

Quantitative Liver-Specific Protein Fingerprint in Blood: A Signature for Hepatotoxicity

Zhiyuan Hu, Christopher Lausted, Hyuntae Yoo, Xiaowei Yan, Amy Brightman, Jiankui Chen, Weizhi Wang, Xiangli Bu, Leroy Hood

Theranostics  ·  01 Jan 2014  ·  doi:10.7150/thno.7868

A flexible microneedle array as low-voltage electroporation electrodes for in vivo DNA and siRNA delivery

Zewen Wei, Shuquan Zheng, Renxin Wang, Xiangli Bu, Huailei Ma, Yidi Wu, Ling Zhu, Zhiyuan Hu, Zicai Liang, Zhihong Li

Lab Chip  ·  01 Jan 2014  ·  doi:10.1039/c4lc00800f

A continuous flow microfluidic-MS system for efficient OBOC screening

Weizhi Wang, Zewen Wei, Zihua Wang, Huailei Ma, Xiangli Bu, Zhiyuan Hu

RSC Adv.  ·  01 Jan 2014  ·  doi:10.1039/c4ra12911c

2013

Circulating tumor cells in HER2-positive metastatic breast cancer patients: a valuable prognostic and predictive biomarker

Yi Liu, Qian Liu, Tao Wang, Li Bian, Shaohua Zhang, …, Sha Li, Zhiyuan Hu, Shikai Wu, Bing Liu, Zefei Jiang

BMC Cancer  ·  23 Apr 2013  ·  doi:10.1186/1471-2407-13-202

Glycocapture-Assisted Global Quantitative Proteomics (gagQP) Reveals Multiorgan Responses in Serum Toxicoproteome

Bingyun Sun, Angelita G. Utleg, Zhiyuan Hu, Shizhen Qin, Andrew Keller, …, Denis Lee, Vinita M. Alexander, Jeffrey A. Ranish, Robert L. Moritz, Leroy Hood

Journal of Proteome Research  ·  11 Apr 2013  ·  doi:10.1021/pr301178a

An automated Teflon microfluidic peptide synthesizer

Hui Zheng, Weizhi Wang, Xiaojun Li, Zihua Wang, Leroy Hood, Christopher Lausted, Zhiyuan Hu

Lab on a Chip  ·  01 Jan 2013  ·  doi:10.1039/c3lc50632k

2012

A novel refractive index detection method in voltage scanning surface plasmon resonance system

Kun Wang, Yuhang Wan, Zheng Zheng, Fuchu He, Zhiyuan Hu, Jinsong Zhu

Sensors and Actuators B: Chemical  ·  01 Jul 2012  ·  doi:10.1016/j.snb.2011.12.030

Circulating microRNA-122 as a potential biomarker for liver injury

Jian Ding

Molecular Medicine Reports  ·  15 Mar 2012  ·  doi:10.3892/mmr.2012.838

2011

Label-Free Detection with Surface Plasmon Resonance Imaging

Christopher Lausted, Zhiyuan Hu, Leroy Hood

Methods in Molecular Biology  ·  01 Jan 2011  ·  doi:10.1007/978-1-61779-043-0_20

2009

SPR Imaging for High Throughput, Label-Free Interaction Analysis

Christopher Lausted, Zhiyuan Hu, Leroy Hood, Charles Campbell

Combinatorial Chemistry & High Throughput Screening  ·  01 Sep 2009  ·  doi:10.2174/138620709789104933

Circulating microRNAs, potential biomarkers for drug-induced liver injury

Kai Wang, Shile Zhang, Bruz Marzolf, Pamela Troisch, Amy Brightman, Zhiyuan Hu, Leroy E. Hood, David J. Galas

Proceedings of the National Academy of Sciences  ·  17 Mar 2009  ·  doi:10.1073/pnas.0813371106

2008

Quantitative Serum Proteomics from Surface Plasmon Resonance Imaging

Christopher Lausted, Zhiyuan Hu, Leroy Hood

Molecular & Cellular Proteomics  ·  01 Dec 2008  ·  doi:10.1074/mcp.M800121-MCP200

2007

Quantitative proteomic approaches for biomarker discovery

Zhiyuan Hu, Leroy Hood, Qiang Tian

PROTEOMICS – Clinical Applications  ·  01 Sep 2007  ·  doi:10.1002/prca.200700109

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