胡致远课题组 | Hu Lab Single-cell & Spatial Omics · Regulatory Genomics · Development & Disease

Research / 研究

We study single-cell and spatial omics, gene regulatory networks, and mechanisms of development and disease.

我们聚焦单细胞与空间多组学、基因调控网络，以及发育与疾病机制研究。

Highlighted

RegVelo: gene-regulatory-informed dynamics of single cells
RegVelo: gene-regulatory-informed dynamics of single cells
Weixu Wang, Zhiyuan Hu, Philipp Weiler, Sarah Mayes, Marius Lange, Jingye Wang, Zhengyuan Xue, Tatjana Sauka-Spengler, Fabian J. Theis
bioRxiv  ·  11 Dec 2024  ·  doi:10.1101/2024.12.11.627935
RegVelo
Code
Docs
software single-cell rna-velocity grn method
The Repertoire of Serous Ovarian Cancer Non-genetic Heterogeneity Revealed by Single-Cell Sequencing of Normal Fallopian Tube Epithelial Cells
The Repertoire of Serous Ovarian Cancer Non-genetic Heterogeneity Revealed by Single-Cell Sequencing of Normal Fallopian Tube Epithelial Cells
Zhiyuan Hu, Mara Artibani, Abdulkhaliq Alsaadi, Nina Wietek, Matteo Morotti, …, Stephanie Jones, Vincenzo Cerundolo, Tatjana Sauka-Spengler, Christopher Yau, Ahmed Ashour Ahmed
Cancer Cell  ·  01 Feb 2020  ·  doi:10.1016/j.ccell.2020.01.003
Single-cell profiling of normal fallopian tube epithelial cells; Cancer Cell (2020).
single-cell cancer ovarian-cancer heterogeneity

All Publications / 全部论文

FINE-EM-seq: a rapid isothermal amplification method enabling comprehensive methylome profiling of zebrafish early embryos
FINE-EM-seq: a rapid isothermal amplification method enabling comprehensive methylome profiling of zebrafish early embryos
Chenyang Ding, Qifeng Zhang, Jing Wang, Yanbo Xu, Tiantian Huang, Yanfang Du, Junjie Zhang, Xiang Zhou, Yibin Liu, Zhiyuan Hu
Cell Insight  ·  01 Jun 2026  ·  doi:10.1016/j.cellin.2026.100324
FINE-EM-seq; Cell Insight (2026).
Code
epigenomics methylation zebrafish embryo method
Whole-genome methylation profiling of extracellular vesicle DNA in gastric cancer identifies intercellular communication features
Whole-genome methylation profiling of extracellular vesicle DNA in gastric cancer identifies intercellular communication features
Bingqian Lin, Zhenna Jiao, Shouquan Dong, Weikai Yan, Jinting Jiang, …, Xiaocheng Weng, Hongling Wang, Zhiyuan Hu, Yibin Liu, Xiang Zhou
Nature Communications  ·  29 Aug 2025  ·  doi:10.1038/s41467-025-63435-w
TEMPT; Nature Communications (2025).
Code
epigenomics methylation ev-dna liquid-biopsy method
RegVelo: gene-regulatory-informed dynamics of single cells
RegVelo: gene-regulatory-informed dynamics of single cells
Weixu Wang, Zhiyuan Hu, Philipp Weiler, Sarah Mayes, Marius Lange, Jingye Wang, Zhengyuan Xue, Tatjana Sauka-Spengler, Fabian J. Theis
bioRxiv  ·  11 Dec 2024  ·  doi:10.1101/2024.12.11.627935
RegVelo
Code
Docs
software single-cell rna-velocity grn method
Endothelial regulatory circuits control cranial neural crest migration and plasticity
Endothelial regulatory circuits control cranial neural crest migration and plasticity
Zhiyuan Hu, Sarah Mayes, Weixu Wang, José M. Santos-Pereira, Fabian Theis, Tatjana Sauka-Spengler
bioRxiv  ·  17 Sep 2024  ·  doi:10.1101/2024.09.17.613303
Cranial neural crest regulatory circuits.
Code
development neural-crest multiome perturb-seq grn
Single-cell transcriptomics identifies a WNT7A-FZD5 signaling axis that maintains fallopian tube stem cells in patient-derived organoids
Single-cell transcriptomics identifies a WNT7A-FZD5 signaling axis that maintains fallopian tube stem cells in patient-derived organoids
Abdulkhaliq Alsaadi, Mara Artibani, Zhiyuan Hu, Nina Wietek, Matteo Morotti, …, Jarret Adams, Francesca Silvestri, Sachdev S. Sidhu, Joan S. Brugge, Ahmed Ashour Ahmed
Cell Reports  ·  01 Nov 2023  ·  doi:10.1016/j.celrep.2023.113354
WNT7A-FZD5 organoid work; Cell Reports (2023).
organoid fallopian-tube stem-cell single-cell cancer
Near-infrared fluorescent Aza-BODIPY dyes: Rational structural design and biomedical imaging
Near-infrared fluorescent Aza-BODIPY dyes: Rational structural design and biomedical imaging
Binyu Zhao, Linhong Liao, Yuyan Zhu, Zhiyuan Hu, Fengshou Wu
Journal of Luminescence  ·  01 Nov 2023  ·  doi:10.1016/j.jlumin.2023.120099
Highly luminescent nitrogen and sulfur co-doped carbon dots for Sn2 and S2 sensing and dual-mode anti-counterfeiting
Highly luminescent nitrogen and sulfur co-doped carbon dots for Sn2+ and S2− sensing and dual-mode anti-counterfeiting
Linhong Liao, Xiao Lin, Kai Wang, Zhiyuan Hu, Fengshou Wu
Microchimica Acta  ·  29 Jul 2023  ·  doi:10.1007/s00604-023-05922-9
HER2 Expression in Circulating Tumor Cells as Prognostic and Predictive Biomarkers for Anti HER2 Therapy in Previously Treated Metastatic Colorectal Cancer
HER2 Expression in Circulating Tumor Cells as Prognostic and Predictive Biomarkers for Anti‐HER2 Therapy in Previously Treated Metastatic Colorectal Cancer
Mengting Wang, Ting Xu, Lin Shen, Jian Li, Ling Zhu, Chen Wang, Zhiyuan Hu, Ping Li, Yanlian Yang, Xicheng Wang
Advanced Therapeutics  ·  06 Jul 2023  ·  doi:10.1002/adtp.202300044
Glioblastoma cell-derived exosomes functionalized with peptides as efficient nanocarriers for synergistic chemotherapy of glioblastoma with improved biosafety
Glioblastoma cell-derived exosomes functionalized with peptides as efficient nanocarriers for synergistic chemotherapy of glioblastoma with improved biosafety
Ying Zhou, Long Wang, Lufei Chen, Wei Wu, Zhimin Yang, …, Sujun Jiang, Xuzhen Qin, Zucheng Ye, Zhiyuan Hu, Zihua Wang
Nano Research  ·  05 Jul 2023  ·  doi:10.1007/s12274-023-5921-6
Facile synthesis of efficient red-emissive carbon quantum dots as a multifunctional platform for biosensing and bioimaging
Facile synthesis of efficient red-emissive carbon quantum dots as a multifunctional platform for biosensing and bioimaging
Yuyan Zhu, Guojing Li, Wei Li, Xiaogang Luo, Zhiyuan Hu, Fengshou Wu
Dyes and Pigments  ·  01 Jul 2023  ·  doi:10.1016/j.dyepig.2023.111303
GNPNAT1 is a potential biomarker correlated with immune infiltration and immunotherapy outcome in breast cancer
GNPNAT1 is a potential biomarker correlated with immune infiltration and immunotherapy outcome in breast cancer
Renjie Yuan, Yulu Zhang, Yange Wang, Hongling Chen, Ruiming Zhang, Zhiyuan Hu, Chengsen Chai, Tingmei Chen
Frontiers in Immunology  ·  05 May 2023  ·  doi:10.3389/fimmu.2023.1152678
Impact of changing treatment strategy based on circulating tumor cells on postoperative survival of breast cancer
Impact of changing treatment strategy based on circulating tumor cells on postoperative survival of breast cancer
Zihan Wang, Wei Xu, Yanlian Yang, Guoxuan Gao, Changsheng Teng, …, Yaqian Xu, Ping Li, Zhiyuan Hu, Zhongtao Zhang, Xiang Qu
Frontiers in Oncology  ·  03 Oct 2022  ·  doi:10.3389/fonc.2022.1006909
CaSee: A lightning transfer-learning model directly used to discriminate cancer normal cells from scRNA-seq
CaSee: A lightning transfer-learning model directly used to discriminate cancer/normal cells from scRNA-seq
Yuan Sh, Xiuli Zhang, Zhimin Yang, Jierong Dong, Yuanzhuo Wang, Ying Zhou, Xuejie Li, Caixia Guo, Zhiyuan Hu
Oncogene  ·  03 Oct 2022  ·  doi:10.1038/s41388-022-02478-5
HER2 status of CTCs by peptide-functionalized nanoparticles as the diagnostic biomarker of breast cancer and predicting the efficacy of anti-HER2 treatment
HER2 status of CTCs by peptide-functionalized nanoparticles as the diagnostic biomarker of breast cancer and predicting the efficacy of anti-HER2 treatment
Mengting Wang, Yaxin Liu, Bin Shao, Xiaoran Liu, Zhiyuan Hu, Chen Wang, Huiping Li, Ling Zhu, Ping Li, Yanlian Yang
Frontiers in Bioengineering and Biotechnology  ·  28 Sep 2022  ·  doi:10.3389/fbioe.2022.1015295
Single Cell Transcriptomics identifies a WNT7A-FZD5 Signaling Axis that maintains Fallopian Tube Stem Cells in Patient-derived Organoids
Single Cell Transcriptomics identifies a WNT7A-FZD5 Signaling Axis that maintains Fallopian Tube Stem Cells in Patient-derived Organoids
Abdulkhaliq Alsaadi, Mara Artibani, Zhiyuan Hu, Nina Wietek, Matteo Morotti, …, Jarret Adams, Francesca Silvestri, Sachdev S Sidhu, Joan S. Brugge, Ahmed Ashour Ahmed
bioRxiv  ·  03 Aug 2022  ·  doi:10.1101/2022.08.02.502319
Cellular plasticity in the neural crest and cancer
Cellular plasticity in the neural crest and cancer
Zhiyuan Hu, Tatjana Sauka-Spengler
Current Opinion in Genetics & Development  ·  01 Aug 2022  ·  doi:10.1016/j.gde.2022.101928
A novel peptide-based probe 99mTc-PEG6-RD-PDP2 for the molecular imaging of tumor PD-L2 expression
A novel peptide-based probe 99mTc-PEG6-RD-PDP2 for the molecular imaging of tumor PD-L2 expression
Qi Luo, Yunwei Zhang, Zihua Wang, Yining Sun, Linqing Shi, Yue Yu, Jiyun Shi, Zhiyuan Hu, Fan Wang
Chinese Chemical Letters  ·  01 Jul 2022  ·  doi:10.1016/j.cclet.2022.02.068
Correction to: An evolving story of the metastatic voyage of ovarian cancer cells: cellular and molecular orchestration of the adipose-rich metastatic microenvironment
Correction to: An evolving story of the metastatic voyage of ovarian cancer cells: cellular and molecular orchestration of the adipose-rich metastatic microenvironment
Takeshi Motohara, Kenta Masuda, Matteo Morotti, Yiyan Zheng, Salma El-Sahhar, …, Mara Artibani, Laura Santana Gonzalez, Hidetaka Katabuchi, Hideyuki Saya, Ahmed Ashour Ahmed
Oncogene  ·  06 Jun 2022  ·  doi:10.1038/s41388-022-02356-0
An exploratory study on the detection rate of circulating tumor cells and the prediction of efficacy of neoadjuvant therapyand prognosis in patients with HER-2-positive early breast cancer
An exploratory study on the detection rate of circulating tumor cells and the prediction of efficacy of neoadjuvant therapyand prognosis in patients with HER-2-positive early breast cancer
Jinmei Zhou, Jiangling Wu, Xiaopeng Hao, Ping Li, Huiqiang Zhang, …, Shaohua Zhang, Zefei Jiang, Yanlian Yang, Zhiyuan Hu, Tao Wang
Research Square Platform LLC  ·  27 May 2022  ·  doi:10.21203/rs.3.rs-1667443/v1
Prognostic Relevance of Estrogen Receptor Status in Circulating Tumor Cells in Breast Cancer Patients Treated With Endocrine Therapy
Prognostic Relevance of Estrogen Receptor Status in Circulating Tumor Cells in Breast Cancer Patients Treated With Endocrine Therapy
Ying Zhou, Jinmei Zhou, Jinyi Xiao, Yuehua Wang, Hao Wang, …, Ping Li, Zhiyuan Hu, Yanlian Yang, Zefei Jiang, Tao Wang
Frontiers in Oncology  ·  28 Apr 2022  ·  doi:10.3389/fonc.2022.866293
Corrigendum: Recent Advances in the Application Peptide and Peptoid in Diagnosis Biomarkers of Alzheimer s Disease in Blood
Corrigendum: Recent Advances in the Application Peptide and Peptoid in Diagnosis Biomarkers of Alzheimer's Disease in Blood
Yuxin Guo, Zhiyuan Hu, Zihua Wang
Frontiers in Molecular Neuroscience  ·  21 Feb 2022  ·  doi:10.3389/fnmol.2022.865110
Co-delivery of phagocytosis checkpoint and STING agonist by a Trojan horse nanocapsule for orthotopic glioma immunotherapy
Co-delivery of phagocytosis checkpoint and STING agonist by a Trojan horse nanocapsule for orthotopic glioma immunotherapy
Ying Zhou, Yuxin Guo, Lufei Chen, Xiaoli Zhang, Wei Wu, Zhimin Yang, Xuejie Li, Yuanzhuo Wang, Zhiyuan Hu, Zihua Wang
Theranostics  ·  01 Jan 2022  ·  doi:10.7150/thno.73104
Recent Advances in the Application Peptide and Peptoid in Diagnosis Biomarkers of Alzheimer s Disease in Blood
Recent Advances in the Application Peptide and Peptoid in Diagnosis Biomarkers of Alzheimer’s Disease in Blood
Yuxin Guo, Zhiyuan Hu, Zihua Wang
Frontiers in Molecular Neuroscience  ·  23 Dec 2021  ·  doi:10.3389/fnmol.2021.778955
Fibroblast Activation Protein α Responsive Peptide Assembling Prodrug Nanoparticles for Remodeling the Immunosuppressive Microenvironment and Boosting Cancer Immunotherapy
Fibroblast Activation Protein‐α Responsive Peptide Assembling Prodrug Nanoparticles for Remodeling the Immunosuppressive Microenvironment and Boosting Cancer Immunotherapy
Mengqi Sun, Shaobo Yao, Linyang Fan, Zhiguo Fang, Weibing Miao, Zhiyuan Hu, Zihua Wang
Small  ·  16 Dec 2021  ·  doi:10.1002/smll.202106296
Mouse Organ-Specific Proteins and Functions
Mouse Organ-Specific Proteins and Functions
Bingyun Sun, Cynthia Lorang, Shizhen Qin, Yijuan Zhang, Ken Liu, …, Angelita G. Utleg, Zhiyuan Hu, Kai Wang, Robert L. Moritz, Leroy Hood
Cells  ·  08 Dec 2021  ·  doi:10.3390/cells10123449
Proteomics profiling of colorectal cancer progression identifies PLOD2 as a potential therapeutic target
Proteomics profiling of colorectal cancer progression identifies PLOD2 as a potential therapeutic target
Yingkuan Shao, Kailun Xu, Xi Zheng, Biting Zhou, Xiuli Zhang, …, Jinfan Li, Lirong Chen, Jimin Shao, Shu Zheng, Tiannan Guo
Cancer Communications  ·  04 Dec 2021  ·  doi:10.1002/cac2.12240
Application of Artificial Intelligence Modeling Technology Based on Fluid Biopsy to Diagnose Alzheimer s Disease
Application of Artificial Intelligence Modeling Technology Based on Fluid Biopsy to Diagnose Alzheimer’s Disease
Yuan Sh, Benliang Liu, Jianhu Zhang, Ying Zhou, Zhiyuan Hu, Xiuli Zhang
Frontiers in Aging Neuroscience  ·  03 Dec 2021  ·  doi:10.3389/fnagi.2021.768229
CIDER: an interpretable meta-clustering framework for single-cell RNA-seq data integration and evaluation
CIDER: an interpretable meta-clustering framework for single-cell RNA-seq data integration and evaluation
Zhiyuan Hu, Ahmed A. Ahmed, Christopher Yau
Genome Biology  ·  01 Dec 2021  ·  doi:10.1186/s13059-021-02561-2
CIDER; Genome Biology (2021).
Code
Docs
software single-cell integration clustering method
A mini-review on peptide-based self-assemblies and their biological applications
A mini-review on peptide-based self-assemblies and their biological applications
Chenlei Wang, Linping Fu, Zhiyuan Hu, Yeteng Zhong
Nanotechnology  ·  16 Nov 2021  ·  doi:10.1088/1361-6528/ac2fe3
Mouse Organ Specific Proteins and Functions
Mouse Organ Specific Proteins and Functions
B. Sun, C. Lorang, S. Qin, Y. Zhang, K. Liu, …, P. Flores, Z. Hu, K. Wang, R. Moritz, L. Hood
bioRxiv  ·  01 Nov 2021  ·  doi:10.1101/2021.11.01.466788
Diagnostic AI Modeling and Pseudo Time Series Profiling of AD and PD Based on Individualized Serum Proteome Data
Diagnostic AI Modeling and Pseudo Time Series Profiling of AD and PD Based on Individualized Serum Proteome Data
Jianhu Zhang, Xiuli Zhang, Yuan Sh, Benliang Liu, Zhiyuan Hu
Frontiers in Bioinformatics  ·  22 Oct 2021  ·  doi:10.3389/fbinf.2021.764497
Exome-Wide Association Study Identifies East Asian-Specific Missense Variant MTHFR C136T Influencing Homocysteine Levels in Chinese Populations RH: ExWAS of tHCY in a Chinese Population
Exome-Wide Association Study Identifies East Asian-Specific Missense Variant MTHFR C136T Influencing Homocysteine Levels in Chinese Populations RH: ExWAS of tHCY in a Chinese Population
Tianzi Liu, Mohetaboer Momin, Huiyue Zhou, Qiwen Zheng, Fangfang Fan, …, Xiao Han, Zhiyuan Hu, Changqing Zeng, Fan Liu, Yan Zhang
Frontiers in Genetics  ·  11 Oct 2021  ·  doi:10.3389/fgene.2021.717621
Cobalt-Doped Carbon Quantum Dots with Peroxidase-Mimetic Activity for Ascorbic Acid Detection through Both Fluorometric and Colorimetric Methods
Cobalt-Doped Carbon Quantum Dots with Peroxidase-Mimetic Activity for Ascorbic Acid Detection through Both Fluorometric and Colorimetric Methods
Cheng Li, Jinjin Zeng, Ding Guo, Lei Liu, Liwei Xiong, Xiaogang Luo, Zhiyuan Hu, Fengshou Wu
ACS Applied Materials & Interfaces  ·  05 Oct 2021  ·  doi:10.1021/acsami.1c13198
A comprehensive assessment of the biocompatibility of Magnetospirillum gryphiswaldense MSR-1 bacterial magnetosomes in vitro and in vivo
A comprehensive assessment of the biocompatibility of Magnetospirillum gryphiswaldense MSR-1 bacterial magnetosomes in vitro and in vivo
Xiaohui Nan, Yan Teng, Jiesheng Tian, Zhiyuan Hu, Qiaojun Fang
Toxicology  ·  01 Oct 2021  ·  doi:10.1016/j.tox.2021.152949
Assessment of PD-L1 Expression on Circulating Tumor Cells for Predicting Clinical Outcomes in Patients with Cancer Receiving PD-1 PD-L1 Blockade Therapies
Assessment of PD-L1 Expression on Circulating Tumor Cells for Predicting Clinical Outcomes in Patients with Cancer Receiving PD-1/PD-L1 Blockade Therapies
Zhaoli Tan, Chunyan Yue, Shoujian Ji, Chuanhua Zhao, Ru Jia, …, Qian Yu, Ping Li, Zhiyuan Hu, Yanlian Yang, Jianming Xu
The Oncologist  ·  28 Sep 2021  ·  doi:10.1002/onco.13981
Diagnostic AI Modeling and Pseudo Time Series Profiling of AD and PD Based on Individualized Serum Proteome Data
Diagnostic AI Modeling and Pseudo Time Series Profiling of AD and PD Based on Individualized Serum Proteome Data
Jianhu Zhang, Xiuli zhang, Yuan Sh, Benliang Liu, Zhiyuan Hu
Research Square Platform LLC  ·  27 Jul 2021  ·  doi:10.21203/rs.3.rs-721593/v1
Application of AI Modeling Technology Based on Fluid Biopsy to Diagnose AD
Application of AI Modeling Technology Based on Fluid Biopsy to Diagnose AD
Yuan Sh, Benliang Liu, Jianhu Zhang, Ying Zhou, Zhiyuan Hu, Xiuli zhang
Research Square Platform LLC  ·  27 Jul 2021  ·  doi:10.21203/rs.3.rs-731371/v1
A Microfluidic Chip for Screening and Sequencing of Monoclonal Antibody at a Single-Cell Level
A Microfluidic Chip for Screening and Sequencing of Monoclonal Antibody at a Single-Cell Level
Weikai Zhang, Qin Li, Fei Jia, Zhiyuan Hu, Zewen Wei
Analytical Chemistry  ·  15 Jul 2021  ·  doi:10.1021/acs.analchem.1c00918
Eating disorders treatment experiences and social support: Perspectives from service seekers in mainland China
Eating disorders treatment experiences and social support: Perspectives from service seekers in mainland China
Ruofan Ma, Manning Zhang, Jonathan M. Oakman, Jiping Wang, Siqi Zhu, Chendi Zhao, Zhiyuan Hu, NiCole T. Buchanan
International Journal of Eating Disorders  ·  08 Jun 2021  ·  doi:10.1002/EAT.23565
Biocompatibility of Bacterial Magnetosomes as MRI Contrast Agent: A Long-Term In Vivo Follow-Up Study
Biocompatibility of Bacterial Magnetosomes as MRI Contrast Agent: A Long-Term In Vivo Follow-Up Study
Xiaohui Nan, Wenjia Lai, Dan Li, Jiesheng Tian, Zhiyuan Hu, Qiaojun Fang
Nanomaterials  ·  07 May 2021  ·  doi:10.3390/nano11051235
Adipocyte-like signature in ovarian cancer minimal residual disease identifies metabolic vulnerabilities of tumor initiating cells
Adipocyte-like signature in ovarian cancer minimal residual disease identifies metabolic vulnerabilities of tumor initiating cells
Mara Artibani, Kenta Masuda, Zhiyuan Hu, Pascal C. Rauher, Garry Mallett, …, Christer S. Ejsing, Robin W. Klemm, Christopher Yau, Tatjana Sauka-Spengler, Ahmed A. Ahmed
JCI Insight  ·  04 May 2021  ·  doi:10.1172/jci.insight.147929
Application of Artificial Intelligence Modeling Technology Based on Multi-Omics in Noninvasive Diagnosis of Inflammatory Bowel Disease
Application of Artificial Intelligence Modeling Technology Based on Multi-Omics in Noninvasive Diagnosis of Inflammatory Bowel Disease
Qiongrong Huang, Xiuli Zhang, Zhiyuan Hu
Journal of Inflammation Research  ·  01 May 2021  ·  doi:10.2147/JIR.S306816
The Zinc Finger Protein Zbtb18 Represses Expression of Class I Phosphatidylinositol 3-Kinase Subunits and Inhibits Plasma Cell Differentiation
The Zinc Finger Protein Zbtb18 Represses Expression of Class I Phosphatidylinositol 3-Kinase Subunits and Inhibits Plasma Cell Differentiation
Bin Xie, Tariq E Khoyratty, Enas Abu-Shah, Pablo F Cespedes, Andrew J MacLean, …, Zhiyuan Hu, Ahmed A Ahmed, Michael L Dustin, Irina A Udalova, Tal I Arnon
The Journal of Immunology  ·  01 Apr 2021  ·  doi:10.4049/jimmunol.2000367
Novel Peptide-Based Magnetic Nanoparticle for Mesenchymal Circulating Tumor Cells Detection
Novel Peptide-Based Magnetic Nanoparticle for Mesenchymal Circulating Tumor Cells Detection
Fei Jia, Yuehua Wang, Zhiguo Fang, Jierong Dong, Fanghao Shi, Weikai Zhang, Zihua Wang, Zhiyuan Hu
Analytical Chemistry  ·  31 Mar 2021  ·  doi:10.1021/acs.analchem.1c00577
An interpretable meta-clustering framework for single-cell RNA-Seq data integration and evaluation
An interpretable meta-clustering framework for single-cell RNA-Seq data integration and evaluation
Zhiyuan Hu, Ahmed A. Ahmed, Christopher Yau
bioRxiv  ·  30 Mar 2021  ·  doi:10.1101/2021.03.29.437525
Promises and challenges of adoptive T-cell therapies for solid tumours.
Promises and challenges of adoptive T-cell therapies for solid tumours.
Matteo Morotti, Ashwag Albukhari, Abdulkhaliq Alsaadi, Mara Artibani, James D Brenton, …, Helen White, Nina Wietek, David N Church, David C Wedge, Ahmed A Ahmed
British journal of cancer  ·  29 Mar 2021  ·  pmid:33782566
Mechanistic Drivers of Müllerian Duct Development and Differentiation Into the Oviduct
Mechanistic Drivers of Müllerian Duct Development and Differentiation Into the Oviduct
Laura Santana Gonzalez, Ioanna A. Rota, Mara Artibani, Matteo Morotti, Zhiyuan Hu, Nina Wietek, Abdulkhaliq Alsaadi, Ashwag Albukhari, Tatjana Sauka-Spengler, Ahmed A. Ahmed
Frontiers in Cell and Developmental Biology  ·  08 Mar 2021  ·  doi:10.3389/fcell.2021.605301
The Oxford Classic Links Epithelial-to-Mesenchymal Transition to Immunosuppression in Poor Prognosis Ovarian Cancers
The Oxford Classic Links Epithelial-to-Mesenchymal Transition to Immunosuppression in Poor Prognosis Ovarian Cancers
Zhiyuan Hu, Paula Cunnea, Zhe Zhong, Haonan Lu, Oloruntoba I. Osagie, …, Joanna Hester, Ashwag Albukhari, Eric O. Aboagye, Christina Fotopoulou, Ahmed Ahmed
Clinical Cancer Research  ·  01 Mar 2021  ·  doi:10.1158/1078-0432.CCR-20-2782
Subtraction-free and bisulfite-free specific sequencing of 5-methylcytosine and its oxidized derivatives at base resolution
Subtraction-free and bisulfite-free specific sequencing of 5-methylcytosine and its oxidized derivatives at base resolution
Yibin Liu, Zhiyuan Hu, Jingfei Cheng, Paulina Siejka-Zielińska, Jinfeng Chen, Masato Inoue, Ahmed Ashour Ahmed, Chun-Xiao Song
Nature Communications  ·  27 Jan 2021  ·  doi:10.1038/s41467-021-20920-2
A Microfluidic Chip for Efficient Circulating Tumor Cells Enrichment, Screening, and Single Cell RNA Sequencing
A Microfluidic Chip for Efficient Circulating Tumor Cells Enrichment, Screening, and Single‐Cell RNA Sequencing
Fanghao Shi, Fei Jia, Zewen Wei, Yan Ma, Zhiguo Fang, Weikai Zhang, Zhiyuan Hu
PROTEOMICS  ·  12 Jan 2021  ·  doi:10.1002/pmic.202000060
BCAR1 plays critical roles in the formation and immunoevasion of invasive circulating tumor cells in lung adenocarcinoma
BCAR1 plays critical roles in the formation and immunoevasion of invasive circulating tumor cells in lung adenocarcinoma
Chun-Guo Mao, Sha-sha Jiang, Xiao-yang Wang, Shao-Lin Tao, Bin Jiang, …, Tan Long, Hua Jin, Qun-You Tan, Yi Huang, Bo Deng
International Journal of Biological Sciences  ·  01 Jan 2021  ·  doi:10.7150/ijbs.61790
Ultrasensitive Gastric Cancer Circulating Tumor Cellular i CLDN18.2 i RNA Detection Based on a Molecular Beacon
Ultrasensitive Gastric Cancer Circulating Tumor Cellular CLDN18.2 RNA Detection Based on a Molecular Beacon
Linyang Fan, Xiaoyi Chong, Minzhi Zhao, Fei Jia, Zihua Wang, …, Yanlian Yang, Zhiyuan Hu, Qin Li, Xiaotian Zhang, Lin Shen
Analytical Chemistry  ·  14 Dec 2020  ·  doi:10.1021/acs.analchem.0c04055
A P4 medicine perspective of gut microbiota and prediabetes: Systems analysis and personalized intervention
A P4 medicine perspective of gut microbiota and prediabetes: Systems analysis and personalized intervention
Qiongrong Huang, Qiaojun Fang, Zhiyuan Hu
Journal of Translational Internal Medicine  ·  01 Sep 2020  ·  doi:10.2478/jtim-2020-0020
A Novel CD133- and EpCAM-Targeted Liposome With Redox-Responsive Properties Capable of Synergistically Eliminating Liver Cancer Stem Cells
A Novel CD133- and EpCAM-Targeted Liposome With Redox-Responsive Properties Capable of Synergistically Eliminating Liver Cancer Stem Cells
Zihua Wang, Mengqi Sun, Wang Li, Linyang Fan, Ying Zhou, Zhiyuan Hu
Frontiers in Chemistry  ·  11 Aug 2020  ·  doi:10.3389/fchem.2020.00649
Efficient isolation and quantification of circulating tumor cells in non-small cell lung cancer patients using peptide-functionalized magnetic nanoparticles
Efficient isolation and quantification of circulating tumor cells in non-small cell lung cancer patients using peptide-functionalized magnetic nanoparticles
Naixin Liang, Lei Liu, Ping Li, Yuan Xu, Yingshuo Hou, …, Huihui Xu, Qian Yu, Shanqing Li, Zhiyuan Hu, Yanlian Yang
Journal of Thoracic Disease  ·  01 Aug 2020  ·  doi:10.21037/jtd-20-1026A
Enhanced Immunogenicity of Mitochondrial-Localized Proteins in Cancer Cells
Enhanced Immunogenicity of Mitochondrial-Localized Proteins in Cancer Cells
Gennaro Prota, Uzi Gileadi, Margarida Rei, Ana Victoria Lechuga-Vieco, Ji-Li Chen, …, Jan Rehwinkel, Jose A. Enríquez, Ahmed A. Ahmed, Ton N. Schumacher, Vincenzo Cerundolo
Cancer Immunology Research  ·  01 May 2020  ·  doi:10.1158/2326-6066.cir-19-0467
Imaging and monitoring HER2 expression in breast cancer during trastuzumab therapy with a peptide probe 99mTc-HYNIC-H10F
Imaging and monitoring HER2 expression in breast cancer during trastuzumab therapy with a peptide probe 99mTc-HYNIC-H10F
Yue Wu, Liqiang Li, Zihua Wang, Jiyun Shi, Zhiyuan Hu, Shi Gao, Weibing Miao, Qingjie Ma, Chengyan Dong, Fan Wang
European Journal of Nuclear Medicine and Molecular Imaging  ·  13 Mar 2020  ·  doi:10.1007/s00259-020-04754-6
Diagnosis of Mild Cognitive Impairment and Alzheimer s Disease by the Plasma and Serum Amyloid-beta 42 Assay through Highly Sensitive Peptoid Nanosheet Sensor
Diagnosis of Mild Cognitive Impairment and Alzheimer’s Disease by the Plasma and Serum Amyloid-beta 42 Assay through Highly Sensitive Peptoid Nanosheet Sensor
Houqian Gao, Mingzhu Liu, Zijian Zhao, Caixia Yang, Ling Zhu, Yanning Cai, Yanlian Yang, Zhiyuan Hu
ACS Applied Materials & Interfaces  ·  03 Feb 2020  ·  doi:10.1021/acsami.0c00370
The Repertoire of Serous Ovarian Cancer Non-genetic Heterogeneity Revealed by Single-Cell Sequencing of Normal Fallopian Tube Epithelial Cells
The Repertoire of Serous Ovarian Cancer Non-genetic Heterogeneity Revealed by Single-Cell Sequencing of Normal Fallopian Tube Epithelial Cells
Zhiyuan Hu, Mara Artibani, Abdulkhaliq Alsaadi, Nina Wietek, Matteo Morotti, …, Stephanie Jones, Vincenzo Cerundolo, Tatjana Sauka-Spengler, Christopher Yau, Ahmed Ashour Ahmed
Cancer Cell  ·  01 Feb 2020  ·  doi:10.1016/j.ccell.2020.01.003
Single-cell profiling of normal fallopian tube epithelial cells; Cancer Cell (2020).
single-cell cancer ovarian-cancer heterogeneity
Drug-internalized bacterial swimmers for magnetically manipulable tumor-targeted drug delivery
Drug-internalized bacterial swimmers for magnetically manipulable tumor-targeted drug delivery
Zhichu Xiang, Gexuan Jiang, Di Fan, Jiesheng Tian, Zhiyuan Hu, Qiaojun Fang
Nanoscale  ·  01 Jan 2020  ·  doi:10.1039/d0nr01892a
A microfluidic chip for screening high-producing hybridomas at single cell level
A microfluidic chip for screening high-producing hybridomas at single cell level
Weikai Zhang, Ren Li, Fei Jia, Zhiyuan Hu, Qin Li, Zewen Wei
Lab on a Chip  ·  01 Jan 2020  ·  doi:10.1039/d0lc00847h
Etiologic and treatment conceptualizations of disordered eating symptoms among mainland Chinese therapists
Etiologic and treatment conceptualizations of disordered eating symptoms among mainland Chinese therapists
Ruofan Ma, Kevin P. Capobianco, NiCole T. Buchanan, Zhiyuan Hu, Jonathan M. Oakman
International Journal of Eating Disorders  ·  24 Nov 2019  ·  doi:10.1002/eat.23204
lt;p gt;Breakthroughs in medicine and bioimaging with up-conversion nanoparticles lt; p gt;
<p>Breakthroughs in medicine and bioimaging with up-conversion nanoparticles</p>
Iman Rostami, Hamideh Rezvani, Zhiyuan Hu, Sarah H Shahmoradian
International Journal of Nanomedicine  ·  01 Sep 2019  ·  doi:10.2147/IJN.S221433
A Novel Peptide Probe for Identification of PLS3-Expressed Cancer Cells
A Novel Peptide Probe for Identification of PLS3-Expressed Cancer Cells
Fanghao Shi, Yan Ma, Yixia Qian, Yuehua Wang, Zihua Wang, Minzhi Zhao, Zhiyuan Hu
Analytical Chemistry  ·  11 Jul 2019  ·  doi:10.1021/acs.analchem.9b01061
The repertoire of serous ovarian cancer non-genetic heterogeneity revealed by single-cell sequencing of normal fallopian tube epithelial cells
The repertoire of serous ovarian cancer non-genetic heterogeneity revealed by single-cell sequencing of normal fallopian tube epithelial cells
Zhiyuan Hu, Mara Artibani, Abdulkhaliq Alsaadi, Nina Wietek, Matteo Morotti, …, Hooman Soleymani majd, Vincenzo Cerundolo, Tatjana Sauka-Spengler, Christopher Yau, Ahmed A. Ahmed
bioRxiv  ·  17 Jun 2019  ·  doi:10.1101/672626
Community assessment to advance computational prediction of cancer drug combinations in a pharmacogenomic screen
Community assessment to advance computational prediction of cancer drug combinations in a pharmacogenomic screen
Michael P. Menden, Dennis Wang, Mike J. Mason, Bence Szalai, Krishna C. Bulusu, …, Stephen Fawell, Gustavo Stolovitzky, Justin Guinney, Jonathan R. Dry, Julio Saez-Rodriguez
Nature Communications  ·  17 Jun 2019  ·  doi:10.1038/s41467-019-09799-2
Peptosome Coadministration Improves Nanoparticle Delivery to Tumors through NRP1-Mediated Co-Endocytosis
Peptosome Coadministration Improves Nanoparticle Delivery to Tumors through NRP1-Mediated Co-Endocytosis
Zhichu Xiang, Gexuan Jiang, Xiaoliang Yang, Di Fan, Xiaohui Nan, Dan Li, Zhiyuan Hu, Qiaojun Fang
Biomolecules  ·  05 May 2019  ·  doi:10.3390/biom9050172
Boosting the Theranostic Effect of Liposomal Probes toward Prominin-1 through Optimized Dual-Site Targeting
Boosting the Theranostic Effect of Liposomal Probes toward Prominin-1 through Optimized Dual-Site Targeting
Yuehua Wang, Fei Jia, Zihua Wang, Yixia Qian, Linyang Fan, He Gong, Aiqin Luo, Jian Sun, Zhiyuan Hu, Weizhi Wang
Analytical Chemistry  ·  28 Mar 2019  ·  doi:10.1021/acs.analchem.9b00622
Plastin 3 down-regulation augments the sensitivity of MDA-MB-231 cells to paclitaxel via the p38 MAPK signalling pathway
Plastin 3 down-regulation augments the sensitivity of MDA-MB-231 cells to paclitaxel via the p38 MAPK signalling pathway
Yan Ma, Wenjia Lai, Minzhi Zhao, Chunyan Yue, Fanghao Shi, Ren Li, Zhiyuan Hu
Artificial Cells, Nanomedicine, and Biotechnology  ·  04 Mar 2019  ·  doi:10.1080/21691401.2019.1576707
Microenvironment Induced In Situ Self Assembly of Polymer Peptide Conjugates That Attack Solid Tumors Deeply
Microenvironment‐Induced In Situ Self‐Assembly of Polymer–Peptide Conjugates That Attack Solid Tumors Deeply
Yong Cong, Lei Ji, Yu‐Juan Gao, Fu‐Hua Liu, Dong‐Bing Cheng, Zhiyuan Hu, Zeng‐Ying Qiao, Hao Wang
Angewandte Chemie International Edition  ·  27 Feb 2019  ·  doi:10.1002/anie.201900135
Detection of Parkinson s Disease through the Peptoid Recognizing α-Synuclein in Serum
Detection of Parkinson’s Disease through the Peptoid Recognizing α-Synuclein in Serum
Houqian Gao, Zijian Zhao, Zhaohui He, Huayi Wang, Mingzhu Liu, Zhiyuan Hu, Oumei Cheng, Yanlian Yang, Ling Zhu
ACS Chemical Neuroscience  ·  25 Jan 2019  ·  doi:10.1021/acschemneuro.8b00540
Anti-PD-1 Antibody SHR-1210 Combined with Apatinib for Advanced Hepatocellular Carcinoma, Gastric, or Esophagogastric Junction Cancer: An Open-label, Dose Escalation and Expansion Study
Anti-PD-1 Antibody SHR-1210 Combined with Apatinib for Advanced Hepatocellular Carcinoma, Gastric, or Esophagogastric Junction Cancer: An Open-label, Dose Escalation and Expansion Study
Jianming Xu, Yun Zhang, Ru Jia, Chunyan Yue, Lianpeng Chang, …, Yan Wang, Xin Yi, Zhiyuan Hu, Jianjun Zou, Quanren Wang
Clinical Cancer Research  ·  15 Jan 2019  ·  doi:10.1158/1078-0432.CCR-18-2484
Proteomic profiling of RAW264.7 macrophage cells exposed to graphene oxide: insights into acute cellular responses
Proteomic profiling of RAW264.7 macrophage cells exposed to graphene oxide: insights into acute cellular responses
Xiaoliang Yang, Yan Zhang, Wenjia Lai, Zhichu Xiang, Bin Tu, Dan Li, Xiaohui Nan, Chunying Chen, Zhiyuan Hu, Qiaojun Fang
Nanotoxicology  ·  02 Jan 2019  ·  doi:10.1080/17435390.2018.1530389
Tumor-microenvironment controlled nanomicelles with AIE property for boosting cancer therapy and apoptosis monitoring
Tumor-microenvironment controlled nanomicelles with AIE property for boosting cancer therapy and apoptosis monitoring
Yixia Qian, Yuehua Wang, Fei Jia, Zihua Wang, Chunyan Yue, Weikai Zhang, Zhiyuan Hu, Weizhi Wang
Biomaterials  ·  01 Jan 2019  ·  doi:10.1016/j.biomaterials.2018.10.003
Synergetic estrogen receptor-targeting liposome nanocarriers with anti-phagocytic properties for enhanced tumor theranostics
Synergetic estrogen receptor-targeting liposome nanocarriers with anti-phagocytic properties for enhanced tumor theranostics
Yuehua Wang, Zihua Wang, Yixia Qian, Linyang Fan, Chunyan Yue, Fei Jia, Jian Sun, Zhiyuan Hu, Weizhi Wang
Journal of Materials Chemistry B  ·  01 Jan 2019  ·  doi:10.1039/c8tb03351j
MMP-2-Controlled Transforming Micelles for Heterogeneic Targeting and Programmable Cancer Therapy
MMP-2-Controlled Transforming Micelles for Heterogeneic Targeting and Programmable Cancer Therapy
Zihua Wang, Yuehua Wang, Xiangqian Jia, Qiuju Han, Yixia Qian, Qian Li, Junfeng Xiang, Qian Wang, Zhiyuan Hu, Weizhi Wang
Theranostics  ·  01 Jan 2019  ·  doi:10.7150/thno.30915
Device for whole genome sequencing single circulating tumor cells from whole blood
Device for whole genome sequencing single circulating tumor cells from whole blood
Ren Li, Fei Jia, Weikai Zhang, Fanghao Shi, Zhiguo Fang, Hong Zhao, Zhiyuan Hu, Zewen Wei
Lab on a Chip  ·  01 Jan 2019  ·  doi:10.1039/c9lc00473d
A Microfluidic Chip for Screening High-Producing Hybridomas at the Single-Cell Level
A Microfluidic Chip for Screening High-Producing Hybridomas at the Single-Cell Level
Wei K. Zhang, Ren Li, Zhi G. Fang, Zhi Y. Hu, Ze W. Wei, Qin Li
2019 IEEE 32nd International Conference on Micro Electro Mechanical Systems (MEMS)  ·  01 Jan 2019  ·  doi:10.1109/MEMSYS.2019.8870728
A Microfluidic Chip for CTC Whole Genome Sequencing
A Microfluidic Chip for CTC Whole Genome Sequencing
Li Ren, Jia Fei, W.K. Zhang, Z.G. Fang, Z.Y. Hu, Z.W. Wei
2019 IEEE 32nd International Conference on Micro Electro Mechanical Systems (MEMS)  ·  01 Jan 2019  ·  doi:10.1109/MEMSYS.2019.8870769
An evolving story of the metastatic voyage of ovarian cancer cells: cellular and molecular orchestration of the adipose-rich metastatic microenvironment
An evolving story of the metastatic voyage of ovarian cancer cells: cellular and molecular orchestration of the adipose-rich metastatic microenvironment
Takeshi Motohara, Kenta Masuda, Matteo Morotti, Yiyan Zheng, Salma El-Sahhar, …, Mara Artibani, Laura Santana Gonzalez, Hidetaka Katabuchi, Hideyuki Saya, Ahmed Ashour Ahmed
Oncogene  ·  19 Dec 2018  ·  doi:10.1038/s41388-018-0637-x
Targeting Peptide Based Probes for Molecular Imaging and Diagnosis
Targeting Peptide‐Based Probes for Molecular Imaging and Diagnosis
Weizhi Wang, Zhiyuan Hu
Advanced Materials  ·  07 Dec 2018  ·  doi:10.1002/adma.201804827
Prospect of liquid biopsy application for precise medication of PD-1 PD-L1 inhibitor
Prospect of liquid biopsy application for precise medication of PD-1/PD-L1 inhibitor
Yuehua Wang, Mengqi Sun, Zhiyuan Hu
Chinese Science Bulletin  ·  21 Nov 2018  ·  doi:10.1360/N972018-00859
Design of a Simple and Practical Nanosystem Coordinates Tumor Targeting and Penetration for Improved Theranostics
Design of a Simple and Practical Nanosystem Coordinates Tumor Targeting and Penetration for Improved Theranostics
Zhichu Xiang, Xiaoliang Yang, Gexuan Jiang, Di Fan, Lingling Geng, Hao Wang, Zhiyuan Hu, Qiaojun Fang
Advanced Therapeutics  ·  21 Oct 2018  ·  doi:10.1002/adtp.201800107
Quantitative proteomic analysis to the first commercialized liposomal paclitaxel nano-platform Lipusu revealed the molecular mechanism of the enhanced anti-tumor effect
Quantitative proteomic analysis to the first commercialized liposomal paclitaxel nano-platform Lipusu revealed the molecular mechanism of the enhanced anti-tumor effect
Minzhi Zhao, Haiyun Li, Linyang Fan, Yan Ma, He Gong, Wenjia Lai, Qiaojun Fang, Zhiyuan Hu
Artificial Cells, Nanomedicine, and Biotechnology  ·  19 Sep 2018  ·  doi:10.1080/21691401.2018.1489822
Quantitative Proteomic Analysis of Cell Responses to Electroporation, a Classical Gene Delivery Approach
Quantitative Proteomic Analysis of Cell Responses to Electroporation, a Classical Gene Delivery Approach
Minzhi Zhao, Deyao Zhao, Yan Ma, Zhiyuan Hu, Zewen Wei
PROTEOMICS  ·  01 Aug 2018  ·  doi:10.1002/pmic.201800127
A Plasmon-Enhanced Fluorescence Protein Microchip with High-Sensitivity for Multiple Islet Autoantibodies Measurements in Autoimmune Diabetes Diagnosis
A Plasmon-Enhanced Fluorescence Protein Microchip with High-Sensitivity for Multiple Islet Autoantibodies Measurements in Autoimmune Diabetes Diagnosis
Yiwen Liu, Jine Li, Juanxia Wu, Fan Ping, Lingling Xu, Qi Sun, Ying Liu, Yuxiu Li, Zhiyuan Hu, Liming Xie
Journal of Biomedical Nanotechnology  ·  01 Aug 2018  ·  doi:10.1166/jbn.2018.2600
IGFBP7 is associated to prognosis and could suppress cell survival in cholangiocarcinoma
IGFBP7 is associated to prognosis and could suppress cell survival in cholangiocarcinoma
Chunyan Yue, Manyi Yang, Qinggang Tian, Fongming Mo, Jian Peng, Yan Ma, Yanning Huang, Dongcui Wang, Yuehua Wang, Zhiyuan Hu
Artificial Cells, Nanomedicine, and Biotechnology  ·  10 Jul 2018  ·  doi:10.1080/21691401.2018.1470524
Molecular Cancer Imaging in the Second Near Infrared Window Using a Renal Excreted NIR II Fluorophore Peptide Probe
Molecular Cancer Imaging in the Second Near‐Infrared Window Using a Renal‐Excreted NIR‐II Fluorophore‐Peptide Probe
Weizhi Wang, Zhuoran Ma, Shoujun Zhu, Hao Wan, Jingying Yue, …, Hongpeng Gao, Junshan Ruan, Zhiyuan Hu, Yongye Liang, Hongjie Dai
Advanced Materials  ·  23 Apr 2018  ·  doi:10.1002/adma.201800106
Dynamic change of PD-L1 expression on circulating tumor cells in advanced solid tumor patients undergoing PD-1 blockade therapy
Dynamic change of PD-L1 expression on circulating tumor cells in advanced solid tumor patients undergoing PD-1 blockade therapy
Chunyan Yue, Yubo Jiang, Ping Li, Yuehua Wang, Jian Xue, …, Ruina Wang, Yongjun Dang, Zhiyuan Hu, Yanlian Yang, Jianming Xu
OncoImmunology  ·  06 Mar 2018  ·  doi:10.1080/2162402X.2018.1438111
pH-Triggered Peptide Self-Assembly for Targeting Imaging and Therapy toward Angiogenesis with Enhanced Signals
pH-Triggered Peptide Self-Assembly for Targeting Imaging and Therapy toward Angiogenesis with Enhanced Signals
Yixia Qian, Weizhi Wang, Zihua Wang, Xiangqian Jia, Qiuju Han, Iman Rostami, Yuehua Wang, Zhiyuan Hu
ACS Applied Materials & Interfaces  ·  14 Feb 2018  ·  doi:10.1021/acsami.8b00583
Generation of a monoclonal antibody recognizing the heavily glycosylated CD45 protein and its application on identifying circulating tumor cells
Generation of a monoclonal antibody recognizing the heavily glycosylated CD45 protein and its application on identifying circulating tumor cells
Weikai Zhang, Zhitao Li, Zihua Wang, Chunyan Yue, Hui Zheng, Ren Li, Mingxing Zhou, Zhiyuan Hu, Zewen Wei, Qin Li
PLOS ONE  ·  09 Feb 2018  ·  doi:10.1371/journal.pone.0192506
Device To Study the Cell Invasion Behavior and Phenotypic Profile at Single Cell Level
Device To Study the Cell Invasion Behavior and Phenotypic Profile at Single Cell Level
Ren Li, Yan Ma, Minzhi Zhao, Zhiyuan Hu, Zewen Wei
Analytical Chemistry  ·  22 Jan 2018  ·  doi:10.1021/acs.analchem.7b03294
Multiple single cell screening and DNA MDA amplification chip for oncogenic mutation profiling
Multiple single cell screening and DNA MDA amplification chip for oncogenic mutation profiling
Ren Li, Mingxing Zhou, Chunyan Yue, Weikai Zhang, Yan Ma, Hailin Peng, Zhiyuan Hu, Zewen Wei
Lab on a Chip  ·  01 Jan 2018  ·  doi:10.1039/c7lc00924k
Identifying EGFR-Expressed Cells and Detecting EGFR Multi-Mutations at Single-Cell Level by Microfluidic Chip
Identifying EGFR-Expressed Cells and Detecting EGFR Multi-Mutations at Single-Cell Level by Microfluidic Chip
Ren Li, Mingxing Zhou, Jine Li, Zihua Wang, Weikai Zhang, Chunyan Yue, Yan Ma, Hailin Peng, Zewen Wei, Zhiyuan Hu
Nano-Micro Letters  ·  14 Nov 2017  ·  doi:10.1007/s40820-017-0168-y
Boosting the down-shifting luminescence of rare-earth nanocrystals for biological imaging beyond 1500 nm
Boosting the down-shifting luminescence of rare-earth nanocrystals for biological imaging beyond 1500 nm
Yeteng Zhong, Zhuoran Ma, Shoujun Zhu, Jingying Yue, Mingxi Zhang, …, Weizhi Wang, Ngan F. Huang, Jian Luo, Zhiyuan Hu, Hongjie Dai
Nature Communications  ·  29 Sep 2017  ·  doi:10.1038/s41467-017-00917-6
Reconfigurable Peptide Nanotherapeutics at Tumor Microenvironmental pH
Reconfigurable Peptide Nanotherapeutics at Tumor Microenvironmental pH
Zeng-Ying Qiao, Wen-Jing Zhao, Yu-Juan Gao, Yong Cong, Lina Zhao, Zhiyuan Hu, Hao Wang
ACS Applied Materials & Interfaces  ·  31 Aug 2017  ·  doi:10.1021/acsami.7b09033
A pan-cancer genome-wide analysis reveals tumour dependencies by induction of nonsense-mediated decay
A pan-cancer genome-wide analysis reveals tumour dependencies by induction of nonsense-mediated decay
Zhiyuan Hu, Christopher Yau, Ahmed Ashour Ahmed
Nature Communications  ·  26 Jun 2017  ·  doi:10.1038/ncomms15943
Antibody Mimetic Peptoid Nanosheet for Label Free Serum Based Diagnosis of Alzheimer s Disease
Antibody‐Mimetic Peptoid Nanosheet for Label‐Free Serum‐Based Diagnosis of Alzheimer's Disease
Ling Zhu, Zijian Zhao, Peng Cheng, Zhaohui He, Zhiqiang Cheng, Jiaxi Peng, Huayi Wang, Chen Wang, Yanlian Yang, Zhiyuan Hu
Advanced Materials  ·  12 Jun 2017  ·  doi:10.1002/adma.201700057
Peptide probes derived from pertuzumab by molecular dynamics modeling for HER2 positive tumor imaging
Peptide probes derived from pertuzumab by molecular dynamics modeling for HER2 positive tumor imaging
Xiaoliang Yang, Zihua Wang, Zhichu Xiang, Dan Li, Zhiyuan Hu, Wei Cui, Lingling Geng, Qiaojun Fang
PLOS Computational Biology  ·  13 Apr 2017  ·  doi:10.1371/journal.pcbi.1005441
Interaction of gold and silver nanoparticles with human plasma: Analysis of protein corona reveals specific binding patterns
Interaction of gold and silver nanoparticles with human plasma: Analysis of protein corona reveals specific binding patterns
Wenjia Lai, Qingsong Wang, Lumeng Li, Zhiyuan Hu, Jiankui Chen, Qiaojun Fang
Colloids and Surfaces B: Biointerfaces  ·  01 Apr 2017  ·  doi:10.1016/j.colsurfb.2017.01.037
Nanoparticle abraxane possesses impaired proliferation in A549 cells due to the underexpression of glucosamine 6-phosphate N-acetyltransferase 1 GNPNAT1 GNA1
Nanoparticle abraxane possesses impaired proliferation in A549 cells due to the underexpression of glucosamine 6-phosphate N-acetyltransferase 1 (GNPNAT1/GNA1)
Minzhi Zhao, Haiyun Li, Yan Ma, He Gong, Shu Yang, Qiaojun Fang, Zhiyuan Hu
International Journal of Nanomedicine  ·  01 Mar 2017  ·  doi:10.2147/IJN.S129976
SPECT CT Imaging of the Novel HER2-Targeted Peptide Probe sup 99m sup Tc-HYNIC-H6F in Breast Cancer Mouse Models
SPECT/CT Imaging of the Novel HER2-Targeted Peptide Probe 99mTc-HYNIC-H6F in Breast Cancer Mouse Models
Liqiang Li, Yue Wu, Zihua Wang, Bing Jia, Zhiyuan Hu, Chengyan Dong, Fan Wang
Journal of Nuclear Medicine  ·  19 Jan 2017  ·  doi:10.2967/jnumed.116.183863
Tumor detection using magnetosome nanoparticles functionalized with a newly screened EGFR HER2 targeting peptide
Tumor detection using magnetosome nanoparticles functionalized with a newly screened EGFR/HER2 targeting peptide
Zhichu Xiang, Xiaoliang Yang, Junjie Xu, Wenjia Lai, Zihua Wang, Zhiyuan Hu, Jiesheng Tian, Lingling Geng, Qiaojun Fang
Biomaterials  ·  01 Jan 2017  ·  doi:10.1016/j.biomaterials.2016.11.022
Targeting peptide functionalized liposomes towards aminopeptidase N for precise tumor diagnosis and therapy
Targeting peptide functionalized liposomes towards aminopeptidase N for precise tumor diagnosis and therapy
Xiangqian Jia, Qiuju Han, Zihua Wang, Yixia Qian, Yunhong Jia, Weizhi Wang, Zhiyuan Hu
Biomaterials Science  ·  01 Jan 2017  ·  doi:10.1039/c6bm00898d
Precisely Enumerating Circulating Tumor Cells Utilizing a Multi-Functional Microfluidic Chip and Unique Image Interpretation Algorithm
Precisely Enumerating Circulating Tumor Cells Utilizing a Multi-Functional Microfluidic Chip and Unique Image Interpretation Algorithm
Mingxing Zhou, Hui Zheng, Zhaoba Wang, Ren Li, Xiaoran Liu, Weikai Zhang, Zihua Wang, Huiping Li, Zewen Wei, Zhiyuan Hu
Theranostics  ·  01 Jan 2017  ·  doi:10.7150/thno.20440
Antiamyloidogenic Activity of Aβ42-Binding Peptoid in Modulating Amyloid Oligomerization
Antiamyloidogenic Activity of Aβ42-Binding Peptoid in Modulating Amyloid Oligomerization
Zijian Zhao, Ling Zhu, Haiyun Li, Peng Cheng, Jiaxi Peng, Yudan Yin, Yang Yang, Chen Wang, Zhiyuan Hu, Yanlian Yang
Small  ·  07 Oct 2016  ·  doi:10.1002/smll.201602857
Switchable Liposomes: Targeting-Peptide-Functionalized and pH-Triggered Cytoplasmic Delivery
Switchable Liposomes: Targeting-Peptide-Functionalized and pH-Triggered Cytoplasmic Delivery
Qiuju Han, Weizhi Wang, Xiangqian Jia, Yixia Qian, Qian Li, Zihua Wang, Weikai Zhang, Shu Yang, Yunhong Jia, Zhiyuan Hu
ACS Applied Materials & Interfaces  ·  12 Jul 2016  ·  doi:10.1021/acsami.6b05678
Self-Assembled ROS-Sensitive Polymer Peptide Therapeutics Incorporating Built-in Reporters for Evaluation of Treatment Efficacy
Self-Assembled ROS-Sensitive Polymer–Peptide Therapeutics Incorporating Built-in Reporters for Evaluation of Treatment Efficacy
Zeng-Ying Qiao, Wen-Jing Zhao, Yong Cong, Di Zhang, Zhiyuan Hu, Zhong-Yu Duan, Hao Wang
Biomacromolecules  ·  08 Apr 2016  ·  doi:10.1021/acs.biomac.6b00041
Response of Human Osteoblast to n-HA PEEK Quantitative Proteomic Study of Bio-effects of Nano-Hydroxyapatite Composite
Response of Human Osteoblast to n-HA/PEEK—Quantitative Proteomic Study of Bio-effects of Nano-Hydroxyapatite Composite
Minzhi Zhao, Haiyun Li, Xiaochen Liu, Jie Wei, Jianguo Ji, Shu Yang, Zhiyuan Hu, Shicheng Wei
Scientific Reports  ·  09 Mar 2016  ·  doi:10.1038/srep22832
Micromixer Based Preparation of Functionalized Liposomes and Targeting Drug Delivery
Micromixer Based Preparation of Functionalized Liposomes and Targeting Drug Delivery
Xiangqian Jia, Weizhi Wang, Qiuju Han, Zihua Wang, Yunhong Jia, Zhiyuan Hu
ACS Medicinal Chemistry Letters  ·  16 Feb 2016  ·  doi:10.1021/acsmedchemlett.6b00028
Switchable probes: pH-triggered and VEGFR2 targeted peptides screening through imprinting microarray
Switchable probes: pH-triggered and VEGFR2 targeted peptides screening through imprinting microarray
Yixia Qian, Weizhi Wang, Zihua Wang, Qiuju Han, Xiangqian Jia, Shu Yang, Zhiyuan Hu
Chemical Communications  ·  01 Jan 2016  ·  doi:10.1039/c6cc01302c
Peptide-conjugated PEGylated PAMAM as a highly affinitive nanocarrier towards HER2-overexpressing cancer cells
Peptide-conjugated PEGylated PAMAM as a highly affinitive nanocarrier towards HER2-overexpressing cancer cells
Iman Rostami, ZiJian Zhao, ZiHua Wang, WeiKai Zhang, Yeteng Zhong, Qiang Zeng, XinRu Jia, ZhiYuan Hu
RSC Advances  ·  01 Jan 2016  ·  doi:10.1039/C6RA19552K
Peptide functionalized targeting liposomes: for nanoscale drug delivery towards angiogenesis
Peptide functionalized targeting liposomes: for nanoscale drug delivery towards angiogenesis
Qiuju Han, Xiangqian Jia, Yixia Qian, Zihua Wang, Shu Yang, Yunhong Jia, Weizhi Wang, Zhiyuan Hu
Journal of Materials Chemistry B  ·  01 Jan 2016  ·  doi:10.1039/c6tb01823h
High-Throughput Peptide Screening on a Bimodal Imprinting Chip Through MS-SPRi Integration
High-Throughput Peptide Screening on a Bimodal Imprinting Chip Through MS-SPRi Integration
Weizhi Wang, Qiaojun Fang, Zhiyuan Hu
Methods in Molecular Biology  ·  01 Jan 2016  ·  doi:10.1007/978-1-4939-3037-1_9
HER2 Targeting Peptides Screening and Applications in Tumor Imaging and Drug Delivery
HER2 Targeting Peptides Screening and Applications in Tumor Imaging and Drug Delivery
Lingling Geng, Zihua Wang, Xiangqian Jia, Qiuju Han, Zhichu Xiang, …, Di Zhang, Xiangli Bu, Weizhi Wang, Zhiyuan Hu, Qiaojun Fang
Theranostics  ·  01 Jan 2016  ·  doi:10.7150/thno.14302
Pathological Condition Driven Construction of Supramolecular Nanoassemblies for Bacterial Infection Detection
Pathological‐Condition‐Driven Construction of Supramolecular Nanoassemblies for Bacterial Infection Detection
Li‐Li Li, Huai‐Lei Ma, Guo‐Bin Qi, Di Zhang, Faquan Yu, Zhiyuan Hu, Hao Wang
Advanced Materials  ·  16 Nov 2015  ·  doi:10.1002/adma.201503437
Discovering of Tumor targeting Peptides using Bi functional Microarray
Discovering of Tumor‐targeting Peptides using Bi‐functional Microarray
Weizhi Wang, Zihua Wang, Xiangli Bu, Ren Li, Mingxing Zhou, Zhiyuan Hu
Advanced Healthcare Materials  ·  09 Nov 2015  ·  doi:10.1002/adhm.201500724
Energy Migration Engineering of Bright Rare Earth Upconversion Nanoparticles for Excitation by Light Emitting Diodes
Energy Migration Engineering of Bright Rare‐Earth Upconversion Nanoparticles for Excitation by Light‐Emitting Diodes
Yeteng Zhong, Iman Rostami, Zihua Wang, Hongjie Dai, Zhiyuan Hu
Advanced Materials  ·  22 Sep 2015  ·  doi:10.1002/adma.201502272
Quantitative Proteomic Analysis of Cellular Resistance to the Nanoparticle Abraxane
Quantitative Proteomic Analysis of Cellular Resistance to the Nanoparticle Abraxane
Minzhi Zhao, Haiyun Li, Xiangli Bu, Chunni Lei, Qiaojun Fang, Zhiyuan Hu
ACS Nano  ·  09 Sep 2015  ·  doi:10.1021/acsnano.5b03677
Microarray Based Screening of Peptide Nano Probes for HER2 Positive Tumor
Microarray Based Screening of Peptide Nano Probes for HER2 Positive Tumor
Zihua Wang, Weizhi Wang, Xiangli Bu, Zewen Wei, Lingling Geng, …, Shu Yang, Fan Wang, Christopher Lausted, Leroy Hood, Zhiyuan Hu
Analytical Chemistry  ·  06 Aug 2015  ·  doi:10.1021/acs.analchem.5b01588
Abraxane, the Nanoparticle Formulation of Paclitaxel Can Induce Drug Resistance by Up-Regulation of P-gp
Abraxane, the Nanoparticle Formulation of Paclitaxel Can Induce Drug Resistance by Up-Regulation of P-gp
Minzhi Zhao, Chunni Lei, Yadong Yang, Xiangli Bu, Huailei Ma, He Gong, Juan Liu, Xiangdong Fang, Zhiyuan Hu, Qiaojun Fang
PLOS ONE  ·  16 Jul 2015  ·  doi:10.1371/journal.pone.0131429
Label-free detection microarray for novel peptide ligands screening base on MS SPRi combination
Label-free detection microarray for novel peptide ligands screening base on MS–SPRi combination
Weizhi Wang, Di Zhang, Zewen Wei, Zihua Wang, Xiangli Bu, Shu Yang, Qiaojun Fang, Zhiyuan Hu
Talanta  ·  01 Mar 2015  ·  doi:10.1016/j.talanta.2014.12.012
A Pliable Electroporation Patch ep-Patch for Efficient Delivery of Nucleic Acid Molecules into Animal Tissues with Irregular Surface Shapes
A Pliable Electroporation Patch (ep-Patch) for Efficient Delivery of Nucleic Acid Molecules into Animal Tissues with Irregular Surface Shapes
Zewen Wei, Yuanyu Huang, Deyao Zhao, Zhiyuan Hu, Zhihong Li, Zicai Liang
Scientific Reports  ·  05 Jan 2015  ·  doi:10.1038/srep07618
Structure-based Design of Peptides with High Affinity and Specificity to HER2 Positive Tumors
Structure-based Design of Peptides with High Affinity and Specificity to HER2 Positive Tumors
Lingling Geng, Zihua Wang, Xiaoliang Yang, Dan Li, Wenxi Lian, …, Weizhi Wang, Xiangli Bu, Wenjia Lai, Zhiyuan Hu, Qiaojun Fang
Theranostics  ·  01 Jan 2015  ·  doi:10.7150/thno.12398
Label-free detection of Alzheimer s disease through the ADP3 peptoid recognizing the serum amyloid-beta42 peptide
Label-free detection of Alzheimer’s disease through the ADP3 peptoid recognizing the serum amyloid-beta42 peptide
Zijian Zhao, Ling Zhu, Xiangli Bu, Huailei Ma, Shu Yang, Yanlian Yang, Zhiyuan Hu
Chemical Communications  ·  01 Jan 2015  ·  doi:10.1039/c4cc07037b
Fast assembling microarrays of superparamagnetic Fe sub 3 sub O sub 4 sub Au nanoparticle clusters as reproducible substrates for surface-enhanced Raman scattering
Fast assembling microarrays of superparamagnetic Fe3O4@Au nanoparticle clusters as reproducible substrates for surface-enhanced Raman scattering
Min Ye, Zewen Wei, Fei Hu, Jianxin Wang, Guanglu Ge, Zhiyuan Hu, Mingwang Shao, Shuit-Tong Lee, Jian Liu
Nanoscale  ·  01 Jan 2015  ·  doi:10.1039/c5nr02491a
Distinguishing of tumor cell-targeting peptide ligands through a color-encoding microarray
Distinguishing of tumor cell-targeting peptide ligands through a color-encoding microarray
Zihua Wang, Weizhi Wang, Lingling Geng, Zhiyuan Hu
Lab on a Chip  ·  01 Jan 2015  ·  doi:10.1039/c5lc01010a
Correction: A continuous flow microfluidic-MS system for efficient OBOC screening
Correction: A continuous flow microfluidic-MS system for efficient OBOC screening
Weizhi Wang, Zewen Wei, Zihua Wang, Huailei Ma, Xiangli Bu, Zhiyuan Hu
RSC Advances  ·  01 Jan 2015  ·  doi:10.1039/c4ra90057j
Rapid Screening of Peptide Probes through i In Situ i Single-Bead Sequencing Microarray
Rapid Screening of Peptide Probes through In Situ Single-Bead Sequencing Microarray
Weizhi Wang, Zewen Wei, Di Zhang, Huailei Ma, Zihua Wang, …, Christopher Lausted, Leroy Hood, Qiaojun Fang, Hao Wang, Zhiyuan Hu
Analytical Chemistry  ·  14 Nov 2014  ·  doi:10.1021/ac503454z
Flow-Through Cell Electroporation Microchip Integrating Dielectrophoretic Viable Cell Sorting
Flow-Through Cell Electroporation Microchip Integrating Dielectrophoretic Viable Cell Sorting
Zewen Wei, Xueming Li, Deyao Zhao, Hao Yan, Zhiyuan Hu, Zicai Liang, Zhihong Li
Analytical Chemistry  ·  06 Oct 2014  ·  doi:10.1021/ac502294e
Betaine homocysteine methyltransferase BHMT as a specific and sensitive blood marker for acute liver injury
Betaine homocysteine methyltransferase (BHMT) as a specific and sensitive blood marker for acute liver injury
Huailei Ma, Jing Ning, Xin Jin, Chunming Mao, Xiangli Bu, …, Kun Wang, Christopher Lausted, Leroy Hood, Jiankui Chen, Zhiyuan Hu
Biomarkers  ·  21 Aug 2014  ·  doi:10.3109/1354750X.2014.951880
Label-Free Quantitative Detection of Tumor-Derived Exosomes through Surface Plasmon Resonance Imaging
Label-Free Quantitative Detection of Tumor-Derived Exosomes through Surface Plasmon Resonance Imaging
Ling Zhu, Kun Wang, Jian Cui, Huan Liu, Xiangli Bu, …, He Gong, Christopher Lausted, Leroy Hood, Guang Yang, Zhiyuan Hu
Analytical Chemistry  ·  11 Aug 2014  ·  doi:10.1021/ac5023056
Bimodal Imprint Chips for Peptide Screening: Integration of High-Throughput Sequencing by MS and Affinity Analyses by Surface Plasmon Resonance Imaging
Bimodal Imprint Chips for Peptide Screening: Integration of High-Throughput Sequencing by MS and Affinity Analyses by Surface Plasmon Resonance Imaging
Weizhi Wang, Menglin Li, Zewen Wei, Zihua Wang, Xiangli Bu, …, Yuqiao Wang, Ying Liu, Qin Li, Qiaojun Fang, Zhiyuan Hu
Analytical Chemistry  ·  24 Mar 2014  ·  doi:10.1021/ac500465e
Quantitative Liver-Specific Protein Fingerprint in Blood: A Signature for Hepatotoxicity
Quantitative Liver-Specific Protein Fingerprint in Blood: A Signature for Hepatotoxicity
Zhiyuan Hu, Christopher Lausted, Hyuntae Yoo, Xiaowei Yan, Amy Brightman, Jiankui Chen, Weizhi Wang, Xiangli Bu, Leroy Hood
Theranostics  ·  01 Jan 2014  ·  doi:10.7150/thno.7868
A flexible microneedle array as low-voltage electroporation electrodes for in vivo DNA and siRNA delivery
A flexible microneedle array as low-voltage electroporation electrodes for in vivo DNA and siRNA delivery
Zewen Wei, Shuquan Zheng, Renxin Wang, Xiangli Bu, Huailei Ma, Yidi Wu, Ling Zhu, Zhiyuan Hu, Zicai Liang, Zhihong Li
Lab Chip  ·  01 Jan 2014  ·  doi:10.1039/c4lc00800f
A continuous flow microfluidic-MS system for efficient OBOC screening
A continuous flow microfluidic-MS system for efficient OBOC screening
Weizhi Wang, Zewen Wei, Zihua Wang, Huailei Ma, Xiangli Bu, Zhiyuan Hu
RSC Adv.  ·  01 Jan 2014  ·  doi:10.1039/c4ra12911c
Circulating tumor cells in HER2-positive metastatic breast cancer patients: a valuable prognostic and predictive biomarker
Circulating tumor cells in HER2-positive metastatic breast cancer patients: a valuable prognostic and predictive biomarker
Yi Liu, Qian Liu, Tao Wang, Li Bian, Shaohua Zhang, …, Sha Li, Zhiyuan Hu, Shikai Wu, Bing Liu, Zefei Jiang
BMC Cancer  ·  23 Apr 2013  ·  doi:10.1186/1471-2407-13-202
Glycocapture-Assisted Global Quantitative Proteomics gagQP Reveals Multiorgan Responses in Serum Toxicoproteome
Glycocapture-Assisted Global Quantitative Proteomics (gagQP) Reveals Multiorgan Responses in Serum Toxicoproteome
Bingyun Sun, Angelita G. Utleg, Zhiyuan Hu, Shizhen Qin, Andrew Keller, …, Denis Lee, Vinita M. Alexander, Jeffrey A. Ranish, Robert L. Moritz, Leroy Hood
Journal of Proteome Research  ·  11 Apr 2013  ·  doi:10.1021/pr301178a
An automated Teflon microfluidic peptide synthesizer
An automated Teflon microfluidic peptide synthesizer
Hui Zheng, Weizhi Wang, Xiaojun Li, Zihua Wang, Leroy Hood, Christopher Lausted, Zhiyuan Hu
Lab on a Chip  ·  01 Jan 2013  ·  doi:10.1039/c3lc50632k
A novel refractive index detection method in voltage scanning surface plasmon resonance system
A novel refractive index detection method in voltage scanning surface plasmon resonance system
Kun Wang, Yuhang Wan, Zheng Zheng, Fuchu He, Zhiyuan Hu, Jinsong Zhu
Sensors and Actuators B: Chemical  ·  01 Jul 2012  ·  doi:10.1016/j.snb.2011.12.030
Circulating microRNA-122 as a potential biomarker for liver injury
Circulating microRNA-122 as a potential biomarker for liver injury
Jian Ding
Molecular Medicine Reports  ·  15 Mar 2012  ·  doi:10.3892/mmr.2012.838
Label-Free Detection with Surface Plasmon Resonance Imaging
Label-Free Detection with Surface Plasmon Resonance Imaging
Christopher Lausted, Zhiyuan Hu, Leroy Hood
Methods in Molecular Biology  ·  01 Jan 2011  ·  doi:10.1007/978-1-61779-043-0_20
SPR Imaging for High Throughput, Label-Free Interaction Analysis
SPR Imaging for High Throughput, Label-Free Interaction Analysis
Christopher Lausted, Zhiyuan Hu, Leroy Hood, Charles Campbell
Combinatorial Chemistry & High Throughput Screening  ·  01 Sep 2009  ·  doi:10.2174/138620709789104933
Circulating microRNAs, potential biomarkers for drug-induced liver injury
Circulating microRNAs, potential biomarkers for drug-induced liver injury
Kai Wang, Shile Zhang, Bruz Marzolf, Pamela Troisch, Amy Brightman, Zhiyuan Hu, Leroy E. Hood, David J. Galas
Proceedings of the National Academy of Sciences  ·  17 Mar 2009  ·  doi:10.1073/pnas.0813371106
Quantitative Serum Proteomics from Surface Plasmon Resonance Imaging
Quantitative Serum Proteomics from Surface Plasmon Resonance Imaging
Christopher Lausted, Zhiyuan Hu, Leroy Hood
Molecular & Cellular Proteomics  ·  01 Dec 2008  ·  doi:10.1074/mcp.M800121-MCP200
Quantitative proteomic approaches for biomarker discovery
Quantitative proteomic approaches for biomarker discovery
Zhiyuan Hu, Leroy Hood, Qiang Tian
PROTEOMICS – Clinical Applications  ·  01 Sep 2007  ·  doi:10.1002/prca.200700109