胡致远课题组 | Hu Lab Single-cell & Spatial Omics · Regulatory Genomics · Development & Disease

Projects / 项目

Representative methods, software, and biological discovery projects from Hu Lab.

RegVelo
RegVelo Gene-regulatory-informed dynamics of single cells

RegVelo 是一个 end-to-end 框架,将 splicing dynamics 与 gene regulatory priors 结合,用于推断单细胞 regulatory dynamics、latent time 和 perturbation effects。

Neural crest regulatory circuits
Neural crest regulatory circuits Single-cell multi-omics, spatial transcriptomics and systematic perturbation

该项目整合 multiome、Smart-seq3、MERSCOPE、Perturb-seq 与调控网络分析,用于解析 cranial neural crest migration 和 fate plasticity 的调控逻辑。

TEMPT
TEMPT Whole-genome EV-DNA methylation profiling

TEMPT 是面向 EV-DNA 的低输入、非亚硫酸氢盐全基因组甲基化测序方法,用于胃癌液体活检和细胞间通信特征识别。

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FINE-EM-seq
FINE-EM-seq Rapid isothermal methylome profiling for early embryos

FINE-EM-seq 是面向斑马鱼早期胚胎的快速等温扩增甲基组方法,配套提供 reproducibility analysis repo。

CIDER
CIDER Interpretable meta-clustering for scRNA-seq integration and evaluation

CIDER 是一个用于单细胞整合数据 meta-clustering 与 integration evaluation 的可解释框架,已提供文档站点与可安装 R 包。