Calculate Distance Matrix Using a Single Model

This function computes a similarity matrix by utilising a single linear model for differential expression analysis.

Usage

calculateDistMatOneModel(
  matrix,
  metadata,
  verbose = TRUE,
  method = "voom",
  additional.variate = NULL
)

matrix: A count matrix with rows representing genes or features and columns representing samples or cells.
metadata: A data frame containing metadata corresponding to the samples or cells. Each row should match a column in matrix.
verbose: Logical. If TRUE, the function displays progress messages and a progress bar. The default is TRUE.
method: A character string specifying the method for differential expression analysis. Options are "voom" or "trend", with "trend" as the default.
additional.variate: A character vector of additional variates to include in the linear model for regression.

A similarity matrix.